literature

HBV mutation literature information.

Hepatitis B virus core promoter mutations contribute to hepatocarcinogenesis by deregulating SKP2 and its target, p21.

PMID: 21704589 2011 Gastroenterology

Method: To generate HBx mutants that correspond to mutations in the basal core promoter region, site-directed mutagenesis was performed at amino acid positions I127N (T1753A), K130M/V131I (A1762T/G1764A) (abbreviated as TA mutant) and F132Y (T1768A) using a Quikchange kit (Stratagene) according to the manufacturer's protocol.

Result: We also constructed plasmids encoding mutant HBx (K130M, V131I) proteins of all three genotypes, corresponding to the core promoter TA mutation.

Genetic dissection of naturally occurring basal core promoter mutations of hepatitis B virus reveals a silent phenotype in the overlapping X gene.

PMID: 19439550 2009 The Journal of general virology

Abstract: Due to a compact viral genome organization, BCP1 and BCP2 mutations result in amino acids changes in the overlapping X gene: K130M/V131I and F132Y, respectively.

Hepatitis B virus genotypes/subgenotypes in voluntary blood donors in Makassar, South Sulawesi, Indonesia.

PMID: 19691824 2009 Virology journal

Discussion: Another study also reported that K130M and V131I substitutions, which are corresponding to double mutation in BCP, from Indian inactive carrier were generally high (36.0%).

Hepatitis B virus X mutations occurring naturally associated with clinical severity of liver disease among Korean patients with chronic genotype C infection.

PMID: 18551606 2008 Journal of medical virology

Abstract: All five mutation types (V5M/L, P38S, H94Y, I127T/N, and K130M and V131I) affecting the six codons were found to be related significantly to clinical severity.

Abstract: Among these, two mutation types (V5M/L and K130M and V131I) were observed more frequently in HBeAg negative patients than in HBeAg positive patients.

Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma.

PMID: 18695135 2008 Journal of the National Cancer Institute

Discussion: Mutations in the BCP region, which overlaps the coding sequence for the X antigen of HBV, may result in amino acid changes K130M and V131I in the X antigen.

HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism.

PMID: 16080797 2005 Virology journal

Abstract: A change in the amino acid sequences at positions 130 and 131 in the HBV-X protein (M130K and V131I) produced by T-A point mutations at the nucleic acids level has been associated with severe liver damage and HCC in patients from China and Africa.

Introduction: A double point mutation with a transversion nucleotide from adenine to thymine at nucleotide 1762, K130M with a transition from adenine to guanine at position 1764 V131I (T-A mutations), has been found more frequently in patients with hepatic tumors than in asymptomatic chronic patients from China and Africa.

Result: From group C the T-A mutations were detected in 7 of the 21 sequence

"Biological impacts of ""hot-spot"" mutations of hepatitis B virus X proteins are genotype B and C differentiated."

PMID: 16094714 2005 World journal of gastroenterology

1Abstract: METHODS: Five types of ""hot-spot"" mutations of genotype B or C HBV X genes, which sequentially lead to the amino acid substitutions of HBx as I127T, F132Y, K130M+V131I, I127T+K130M+V131I, or K130M+V131I+F132Y, respectively, were generated by means of site-directed mutagenesis."

Abstract: RESULTS: As compared to standard genotype B HBx, mutants of I127T and I127T+K130M+V131I showed high

Comparison of full length sequences of hepatitis B virus isolates in hepatocellular carcinoma patients and asymptomatic carriers of Korea.

PMID: 15543574 2005 Journal of medical virology

Abstract: Third, mutations (I127T/N, K130M, and V131I) at three codons in the carboxy functional region of X protein were observed in isolates from all three HCC patients.

Lamivudine and Famciclovir resistant hepatitis B virus associated with fatal hepatic failure.

PMID: 12727536 2003 Journal of clinical virology

Abstract: Subsequent to the instigation of antiviral therapy, the dominant drug resistant HBV which caused virological breakthrough and was associated with hepatic failure displayed a series of unique mutations particularly in the BCP (A1762T and G1764A) and in the polymerase (rtL180M, rtM204V, rtA222T and rtL336V), core (cP5T, cS26A,

Hepatitis B virus X gene variability in French-born patients with chronic hepatitis and hepatocellular carcinoma.

PMID: 11002246 2000 Journal of medical virology

1Abstract: The changes K130M and V131I, considered as ""hot spot mutations,"" were found in strains of HCC patients carrying an ayw subtype of the HBV genome but not in the ones of chronically infected patients."

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