literature

HBV mutation literature information.

Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.

PMID: 35390033 2022 PloS one

Introduction: Mutations at T53C, PreS deletions, PreS2 start codon, C7A, A2962G, C2964A and C3116T in the PreS region have been proved that significantly increase risk of HCC.

Complete genome analysis of hepatitis B virus in Qinghai-Tibet plateau: the geographical distribution, genetic diversity, and co-existence of HBsAg and anti-HBs antibodies.

PMID: 32532295 2020 Virology journal

Abstract: Clinical prognosis-related genetic variations such as nucleotide mutation T1762/A1764 (27.93%), A2189C (12.85%), G1613A (8.94%), T1753C (8.38%), T53C (4.47%) T3098C (1.68%) and PreS deletion (2.23%) were detected in CD recombinants.

Discussion: Other mutations, such as T53C, G1613A, C1653T, T1753C, A2189C, T3098C and PreS deletions were also reported associated with clinical progress.

Discussion: The same result was also found in frequencies of mutation A2189C (12.85%),

Molecular characterization of hepatitis B virus in Vietnam.

PMID: 28859616 2017 BMC infectious diseases

Method: The preS2/S1 sequences were analyzed for preS1 deletion, preS1 mutations (A2962G, C3026A/T, C2964A, and C3116T), preS2 start codon deletion, and preS2 mutations (T31C, T53C, A162G, and T531C/G).

Table: T53C

Phosphatase and tensin homologue genetic polymorphisms and their interactions with viral mutations on the risk of hepatocellular carcinoma.

PMID: 25881591 2015 Chinese medical journal

Introduction: We and others have reported that HBV mutations C1653T, T1753V, A1762T/G1764A, T1674C/G, and C1766T/T1768A in the enhancer II/basal core promoter (EnhII/BCP) region; G1899A, C2002T, A2159G, A2189C, and G2203A/T in the precore/core region; as well as T53C,

PMID: 24849936 2014 PloS one

Abstract: RESULTS: After adjustment for age, history of cigarette smoking and alcohol consumption, HBeAg positivity, pre-S deletions, pre-S2 start codon mutations, and T53C mutation were significantly associated with HCC, showing adjusted odds ratios (ORs) from 1.914 to 3.199.

Result: Among these nine hot spot mutations, pre-S deletions, pre-S start codon mutations, T31C, and T53C mutations were significantl

Discussion: We also observed that control subjects showed a significant higher frequency of the synonymous substitution of T53C in pre-S2 region than case patients.

Effects of hepatitis B virus mutations on its replication and liver disease severity.

PMID: 23400390 2013 The open virology journal

Discussion: For example, T3098C in the preS1 region and T53C were associated with HCC but further investigation is essential.

A complete genomic analysis of hepatitis B virus isolated from 516 Chinese patients with different clinical manifestations.

PMID: 23852705 2013 Journal of medical virology

Abstract: Incidences of point mutation T53C (preS1F53L), G1613A (polR841K), G1775A and A1762T + G1764A in the basal core promoter region, G1896A and G1899A in precore region and A2189C (coreI97L) in core region increased along with acute hepatitis B, chronic hepatitis B, and acute-on-chronic liv

Effects of antiviral therapy on the recurrence of hepatocellular carcinoma after curative resection or liver transplantation.

PMID: 23166535 2012 Hepatitis monthly

Introduction: C1653T, T1753V, A1762T/G1764A, T1674C/G, C1766T/T1768A, T53C, preS2 start codon mutation, preS1 deletion, C2964A, A2962G, C3116T, C7A, and their combinations are HBV mutations that are significantly associated with an increased risk of HCC occurrence.

Comparison study on the complete sequence of hepatitis B virus identifies new mutations in core gene associated with hepatocellular carcinoma.

PMID: 20699378 2010 Cancer epidemiology, biomarkers & prevention

Abstract: RESULTS: The pre-S deletion and 12 point mutations, namely, the pre-S2 start codon mutation, T53C in the pre-S2 gene, T766A in the S gene, G1613A, C1653T, A1762T, G1764A in the X gene, and G1899A, C2002T, A2159G, A2189C, and G2203W (A or T) in the pre-C/C gene, showed close associations with

Associations between hepatitis B virus mutations and the risk of hepatocellular carcinoma: a meta-analysis.

PMID: 19574418 2009 Journal of the National Cancer Institute

Table: T53C

Discussion: Other mutations that have been shown to be statistically significantly associated with the risk of HCC, such as those at T31C, T53C, G1613A, A1703G, G1719T, C1726A, and G1730C, were not included because few patients had these mutations.

Browser Board

Co-occurred Entities

Filtrator