literature

HBV mutation literature information.

A336C/A336T/T337C variations in HBV core gene and spontaneous hepatitis B e antigen loss in chronic hepatitis B patients.

PMID: 21569538 2011 Virology journal

Result: A336C/A336T/T337C variations occurred in 40/166(24.1%) chronic hepatitis B patients without any antiviral therapy (See Table 2).

Discussion: Statistical analysis showed A336C/A336T/T337C variations were closely associated with G1896A

Discussion: Therefore, A336C/A336T/T337C variations were proposed to be another major mechanism to explain spontaneous HBeAg loss in the natural history of chronic HBV infection as well as G1896A variation and genotype B.

Clinical significance of a set of single nucleotide polymorphisms of hepatitis B virus core gene in Chinese Han patients with chronic hepatitis B.

PMID: 18814242 2008 Journal of medical virology

Abstract: 5 SNPs, A261T, A336C, A336T T337C and T385C, were found to be associated with RFLP patterns change and only SNP A336C or A336T caused the substitution of Glu-83 with Asp in HBcAg.

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