Distinctive HBV Replication Capacity and Susceptibility to Tenofovir Induced by a Polymerase Point Mutation in Hepatoma Cell Lines and Primary Human Hepatocytes.
PMID: 33562603
2021
International journal of molecular sciences
Result: The
Result: The rtT301A Mutation Decreases Replication Capacity and Increases Tenofovir Resistance in Hepatoma Cell Lines.
Result: The role of the novel rtT301A mutation was investigated using three representative clones (Clones 1-29, 4-7, and 4-8) carrying tenofovir-resistant mutations (CYELMVI), of which Clones 1-29 and 4-7 carried an additional rtT301A mutation (Figure 3a).
Discussion: Herein, we report a novel rtT301A mutation accompanying previously reported tenofovir-resistant mutations (CYELMVI) in a tenofovir-treated CHB patient without complete virological suppression.
HBV mutation literature information.
PMID: 
2021
International journal of molecular sciences
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