Discussion: Also it was found that the frequencies of
T216C,
G1896A,
G1913A/G, and
A2159G/C were >45% in the patients with
ACLF, the combinative mutations at these sites could be utilized to diagnose clinically and to discriminate the
HBV-infected patients with
advanced disease.
Discussion: Thus, according to the results of our investigation, the old HBV patients with genotype B virus and mutations at
T216C,
G1896A,
C1913A/G and
A2159G/C sites may be prone to
ACLF
HBV mutation literature information.
PMID: 
2015
PloS one
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