Precore/core mutations of hepatitis B virus genotype D arising in different states of infection.
PMID: 35415256
2022
Clinical and experimental hepatology
Introduction: showed that the core mutations such as T1938C (V13A) and A2051C (N51H) were correlated with HBV-related HCC and played a role in progression of liver disease in an Alaskan native population with HBV genotype F1b.
An Association Between Core Mutations in Hepatitis B Virus Genotype F1b and Hepatocellular Carcinoma in Alaskan Native People.
Abstract: In the HCC patients, T1938C and A2051C mutations in the core region had accumulated significantly with A1762T/G1764A mutations in the basal core promoter (BCP) region and G1896A mutation in the precore (PC) region.
Potential Susceptibility Mutations in C Gene for Hepatitis B-Related Hepatocellular Carcinoma Identified by a Two-Stage Study in Qidong, China.
PMID: 27727182
2016
International journal of molecular sciences
Result: Meanwhile, the frequencies of hot-spot mutations in the C gene increased in the HCC group, from 6.1% (deletion), 15.2% (T1938C), 11.1% (C2002T), 13.1% (T2045A), 35.4% (A2159G), 40.4% (A2189Y), 10.1% (G2203W), and 22.2% (C2288R) in HCC cases to 2.0%, 7.1%, 7.1%, 14.3%, 20.4%, 22.4%, 2.0%, and 11.2% in controls, respectively.
Hepatitis B virus core variants modify natural course of viral infection and hepatocellular carcinoma progression.
Abstract: The longitudinal study further showed that the appearance of 2 such variants (T1938C and T2045A) was preceded by long-term diminished viral load and decreased rate of liver abnormalities and was significantly less frequent in individuals with a prolonged immune clearance phase that associated with spectrum of liver disease than those in inactive carrier or reactivation phase.
HBV mutation literature information.
PMID: 
2022
Clinical and experimental hepatology
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