Abstract: Further analysis showed that the age of G1721A/A1775G/T1858C containing combined mutation group was significantly lower than that of the non-mutation group [(4.58 +- 2.53) years vs.
The mutation of hepatitis B virus and the prognosis of hepatocellular carcinoma after surgery: a pilot study.
PMID: 29628773
2018
Cancer management and research
Method: According to the sequencing outcome, HBV genotype and mutations (including A1752T/G, T1753C, G1757A, A1762T/G1764A, C1766T, T1768A, A1775G, C1799G, A1846T, T1858C, G1896A, G1898A, G1899A, and Pre S deletion) were confirmed by the BLAST analysis (http://blast.ncbi.nlm.nih.gov/Blast.cgi).
Result: According to different mutation regions, A1752T/G, T1753C,
Broad Range of Hepatitis B Virus (HBV) Patterns, Dual Circulation of Quasi-Subgenotype A3 and HBV/E and Heterogeneous HBV Mutations in HIV-Positive Patients in Gabon.
Discussion: In addition, other combined mutation types such as C1856T/T1858C/G1721A and G1721A/G1757A/A1775G/T1858C were also exclusively detected in children with genotype C infection, while the clinical characteristics of these combined mutation-containing patients showed no statistical difference compared to those without combined mutations.
Discussion: In our results, we showed that 16 of 17 T1858C mutation-containing sequences were in T1858C/A1775G/G1721A triple mutations.
Associations between hepatitis B virus basal core promoter/pre-core region mutations and the risk of acute-on-chronic liver failure: a meta-analysis.
Method: The following mutation sites were also detected in the included studies: G1613A, C1653T, 1752G, T1754V, T1753V/A1762T/G1764A, T1758C, G1764A/C1766T/T1768A, T1770A, 1773 T, G1775A, C1799V, T1800C, T1803C, G1809T, A1814C, A1837G, A1846G, T1853C, PMID: 26564702
2015
Zhonghua liu xing bing xue za zhi
Abstract: CONCLUSION: The present investigation showed that BCP A1762T/
Abstract: Multiple logistic regression analysis indicated that A1762T/G1764A and T1858C mutations are the risk factors for the development of HCC (OR = 5.459, 95% CI: 1.397-21.332, P = 0.015; OR = 3.881, 95% CI: 1.462-10.305, P = 0.006).
Abstract: RESULTS: The mutation rates of the A1762T/G1764A in the BCP region and the T1858C in the Pre-C region of HBV were significantly higher in HCC group than in control group (94.3% vs.
Novel point and combo-mutations in the genome of hepatitis B virus-genotype D: characterization and impact on liver disease progression to hepatocellular carcinoma.
Result: The occurrence of precore mutation, T1858C was noticed with an increasing frequencies of 5.88% in nLF, 11% in LF, 15% in LC and 36% in HCC (p = 0.08).
Result: While the prevalence of Table: T1858C
Discussion: Another precore mutation, T1858C, which makes a pair with G1896A to stabilize the viral encapsidation signal and enhance viral replication, was observed significantly associated with more aggressive course of liver diseases in HBeAg negative HCC (Figure 1) similar to previous study.
Association of Hepatitis B Virus Mutations of A1846T and C1913A/G With Acute-on-Chronic Liver Failure Development From Different Underlying Chronic Liver Diseases.
Result: In addition, since BCP/PC mutations of T1754G, T1758C, C1766T, T1768A, G1862T, and T1858C were observed only in 7, 5, 7, 4, 1, and 4 of ACLF patients, respectively, these mutations were not included in further analysis.
A multicentre molecular analysis of hepatitis B and blood-borne virus coinfections in Viet Nam.
Figure: The mutation T1858C was identified only in genotype C viruses.
A case-control study on sequence variations in the enhancer II/core promoter/precore and X genes of hepatitis B virus in patients with hepatocellular carcinoma.
HBV mutation literature information.
PMID: 
2020
Zhonghua gan zang bing za zhi
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