Introduction: A total of 8 HBV classical mutation sites are conventionally tested for HBV patients in most clinical labs, including M204I/V, L180M, T184A/F/I/L/S, L181T/V, M250I/L/V, M236T, S202G, and V207I.
Discovery of the Novel Entecavir-Resistant Hepatitis B Virus Reverse Transcriptase A181C Substitution From an Integrated Genotypic Analysis.
Result: Due to the presence of ETVr substitutions rt
Result: ETVr substitutions at rtT184 (rtT184C/G/I/S) have been shown to exhibit low-level ETVr and have only been observed in combination with other ETVr substitutions in patients with virologic breakthrough.( 12 ) The novel emergent rtV191I substitution was phenotyped in an ETVr HBV RT background of rtL180M, rtT184S, and rtM204V and displayed reduced ETV susceptibility (15-fold greater than WT; Table 2) within the range observed for LVDr HBV.
A systematic review of hepatitis B virus (HBV) drug and vaccine escape mutations in Africa: A call for urgent action.
Result: Overall, the most prevalent RAM was rtM204V/I in both treatment experienced and treatment naive individuals, and occurring either alone or in combination with other polymorphisms rtL80I/V, rtV173L, rtL180M, rtA181S, rtT184S, rtA200V and/or rtS202S (Fig 3); mutations among individuals with and without exposure to HBV therapy are listed in S4 Table and S5 Table, respectively).
Analysis of HBV basal core promoter/precore gene variability in patients with HBV drug resistance and HIV co-infection in Northwest Ethiopia.
Introduction: According to several clinical practice guidelines and authoritative reviews, NUCr substitutions can be classified into two categories: primary NUCr substitutions at 8 codons (rtI169T, rtA181T/V, rtT184A/C/F/G/I/L/M/S, rtA194T, rtS202C/G/I, rtM204I/V,
Discussion: Substitution rtT184A/S (n = 2) was the only naturally occurring substitution detected as belonging to a typical primary NUCr substitution.
Selection of the highly replicative and partially multidrug resistant rtS78T HBV polymerase mutation during TDF-ETV combination therapy.
Discussion: The presence of rtS78T in addition to rtT184S, rtV173L, rtL180M, and rtM204V, was associated with a two-fold reduction in ETV susceptibility; however, in line with our results, the ETV resistance level for this mutation alone did not exceed 1.8-fold of the level of wild type HBV.
HIV therapy with unknown HBV status is responsible for higher rate of HBV genome variability in Ethiopia.
Abstract: RESULTS: In 34 out of 161 study subjects (21.1%) HBV drug resistance mutations (DRMs) were detected with a frequency of 3.1% rtL80F/I, 0.6% rtA181V, 1.2% rtT184S, 6.2% rtV173L, 10.6% rtL180M, 10.6% rtM204V/I and 8.1% rtI233V.
Evolution of entecavir-resistant hepatitis B virus during entecavir and adefovir dipivoxil combination therapy.
PMID: 26889227
2016
Experimental and therapeutic medicine
Result: rtM204I was outcompeted by other mutants, and became undetectable at month 30, whereas rtM204V and other mutant strains became dominant in the viral population; iv) at month 30 the rtM204V, rtL180M, rtS202G and rtT184S variants were present in ~100, 100, 80 and 15% of the viral population, respectively, which was accompanied by a virological breakthrough.
Result: At this time, the viral strains of rtL180M + rtM204V +
Serologic and genotypic characterization of hepatitis B virus in HIV-1 infected patients from South West and Littoral Regions of Cameroon.
Result: Mutations rtV173L, rtL180M, rtM204V conferring resistance to lamivudine and other L-nucleoside analogues were identified in six patients while one patient had the rtL180M + rtM204V + rtT184S mutations associated with resistance to both L-nucleoside analogues and entecavir.
Table: T184S
Discussion: The rtL180M + rtT184S + rt
De novo entecavir+adefovir dipivoxil+lamivudine triple-resistance mutations resulting from sequential therapy with adefovir dipivoxil, and lamivudine.
PMID: 27079793
2016
Annals of clinical microbiology and antimicrobials
Result: described a patient who received LAM+ADV and then developed de novo ETV resistance with rtM204 V+rtL180 M+rtT184 S mutations.
HBV mutation literature information.
PMID: 
2019
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