Hepatitis B virus subgenotype A1 predominates in liver disease patients from Kerala, India.
PMID: 24409056
2013
World journal of gastroenterology
Abstract: Mutation C1766T/T1768A was significantly associated with genotype A (P = 0.05) and HCC (P = 0.03).
Association of Hepatitis B Virus Mutations of A1846T and C1913A/G With Acute-on-Chronic Liver Failure Development From Different Underlying Chronic Liver Diseases.
Result: In addition, since BCP/PC mutations of T1754G, T1758C, C1766T, T1768A, G1862T, and T1858C were observed only in 7, 5, 7, 4, 1, and 4 of ACLF patients, respectively, these mutations were not included in further analysis.
Effects of antiviral therapy on the recurrence of hepatocellular carcinoma after curative resection or liver transplantation.
Introduction: C1653T, T1753V, A1762T/G1764A, T1674C/G, C1766T/T1768A, T53C, preS2 start codon mutation, preS1 deletion, C2964A, A2962G, C3116T, C7A, and their combinations are HBV mutations that are significantly associated with an increased risk of HCC occurrence.
Variability in the precore and core promoter regions of HBV strains in Morocco: characterization and impact on liver disease progression.
Abstract: CP mutations C1653T, T1753V, A1762T/G1764A, and C1766T/T1768A were associated with higher HBV-DNA level and increased liver disease severity.
Abstract: Multiple logistic regression analysis showed that older age (>= 40 years), male sex, high viral load (>4.3 log(10) IU/mL) and CP mutations C1653T, T1753V, A1762T/G1764A, and C1766T/T1768A were independent risk factors for PMID: 21704589
2011
Gastroenterology
Abstract: METHODS: We constructed a series of HBx mutants with changes in the CP region that correspond to A1762T/G1764A (TA), T1753A, T1768A, or a combination of these (combo) and expressed them, along with wild-type HBx under control of its endogenous promoter, in primary human hepatocytes (PHHs) and HepG2 cells.
Introduction: Besides the TA mutation, other core promoter mutations, notably T1753V and T1768A, have also been reported to be associated with an increased risk of HCC.
Method: To generate HBx mutants that
Association between the various mutations in viral core promoter region to different stages of hepatitis B, ranging of asymptomatic carrier state to hepatocellular carcinoma.
PMID: 20959817
2011
The American journal of gastroenterology
Abstract: C1673T, A1726C, A1727T, C1730G, C1766T, T1768A, C1773T, and C1799G in genotype C were significantly associated with cirrhosis compared with the CHB patients, whereas these mutations were inversely associated with HCC compared with the cirrhosis patients.
A case-control study on sequence variations in the enhancer II/core promoter/precore and X genes of hepatitis B virus in patients with hepatocellular carcinoma.
Abstract: No significant difference between groups was found with respect to G1613A, C1653T, C1766T/T1768A, A1846T/C, T1858C, and G1896A mutations.
Hepatitis B virus genotype and basal core promoter/precore mutations are associated with hepatitis B-related acute-on-chronic liver failure without pre-existing liver cirrhosis.
Abstract: Single mutations including T1753V (C/A/G), A1762T, G1764A, G1896A and G1899A and triple mutations T1753V/A1762T/G1764A and A1762T/G1764A/C1766T (or T1768A) were more frequently detected in patients with HB-ACLF than in patients with CHB.
Introduction: In addition, single mutations including the T1753V (C/A/G), C1766T, T1768A,
Genetic dissection of naturally occurring basal core promoter mutations of hepatitis B virus reveals a silent phenotype in the overlapping X gene.
PMID: 19439550
2009
The Journal of general virology
Abstract: During chronic hepatitis B virus (HBV) infection, double substitution mutations in the basal core promoter (BCP) region frequently emerge that include A1762T/G1764A and the neighbouring C1766T/T1768A mutations, here termed BCP1 and BCP2, respectively.
Chimeric constructs between two hepatitis B virus genomes confirm transcriptional impact of core promoter mutations and reveal multiple effects of core gene mutations.
Discussion: Remarkably, introduction of the C1766T/T1768A double mutation alone into a wild-type background reproduced a 15-fold increase in replication capacity.
Discussion: The high replication capacity was mapped to nucleotides 1574-1986, where 7 core promoter mutations are present: G1751T, T1753A, G1757A, A1762T, G1764A, C1766T, and T1768A.
HBV mutation literature information.
PMID: 
2013
World journal of gastroenterology
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