Effect of basal core promoter and pre-core mutations on hepatitis B virus replication.
PMID: 18343830
2008
The Journal of general virology
Abstract: Substitutions A1762T/G1764A and T1753C, C1766T and T1768A in the BCP region, and G1896A and G1899A in the pre-C region, were examined either alone or in combination, using a common genetic background.
Genome replication, virion secretion, and e antigen expression of naturally occurring hepatitis B virus core promoter mutants.
Abstract: A much higher replication capacity was reported for a naturally occurring core promoter mutant implicated in the outbreak of fulminant hepatitis, which was caused by the neighboring C1766T/T1768A mutations instead.
Hepatitis B virus core promoter mutations in children with multiple anti-HBe/HBeAg reactivations result in enhanced promoter activity.
Abstract: In both patients, rare mutations were found in the BCP at nucleotides 1764(G-->T)/1766(C-->G) and 1766(C-->T)/1768(T-->A) in case 1 and 2, respectively.
HBV mutation literature information.
PMID: 
2008
The Journal of general virology
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