Abstract: In tumor compartments per se, several mis-sense mutations were detected, notably the classic T1762A/A1764G mutation in the basal core promoter.
Table: T1762A
Discussion: Most notable of these and found in all seven tumor samples analyzed in our study was the classic double mutation T1762A/A1764G, in the basal core promoter region (BCP) which has been reported in several studies and is known to be an important pro-oncogenic mutation.
Sequence analysis and functional characterization of full-length hepatitis B virus genomes from Korean cirrhotic patients with or without liver cancer.
Discussion: Transfection studies have shown that the T1762A/G1764A dual mutations decrease the level of pre-C mRNA by 50% to 70%, thereby inhibiting HBeAg production.
Lower mutation frequency of BCP/precore regions in e antigen-negative chronic HBV-infected children instead of adults patients.
Discussion: The other is a two-nucleotide substitution, T1762A and G1764A, and transfection studies have shown that the T1762A and G1764A double mutation decreases the level of pre-C mRNA by 50% to 70%, leading to reduced HBeAg synthesis.
The Effect of HBV Genotype C on the Development of HCC Differs Between Wild-Type Viruses and Those With BCP Double Mutations (T(1762)A(1764)).
Abstract: HBV basal core promoter (BCP) double mutations (T(1762)A(1764)) are very strong confounding factors of genotypes B and C in HCC development.
[Results of a novel real-time PCR, sequence analysis, Inno-LiPA line probe assays in the detection of hepatitis B virus G1896A precore mutation in French blood donors].
Abstract: AIM: To screen hepatitis B virus (HBV) genotypes and associated basal core promoter (BCP; T1762A/A1764) and precore (PC; A1896) mutations among the 100 HBV surface antigen (HBsAg) positive voluntary blood donors in France.
CTL escape mutations of core protein are more frequent in strains of HBeAg negative patients with low levels of HBV DNA.
Abstract: By multivariate analysis, high level (>10(5)copies/mL) of serum HBV DNA was inversely associated with the presence of mutations in CTL epitopes of HBc (OR: 0.11, p=0.015), while it was directly associated with the presence of promoter double T(1762)A(1764) mutations together with G(1757) (OR: 16.87, p=0.004).
A1762T/G1764A mutations of hepatitis B virus, associated with the increased risk of hepatocellular carcinoma, reduce basal core promoter activities.
PMID: 18675784
2008
Biochemical and biophysical research communications
Abstract: We also show that T1762A and G1764A double mutations synergize the reduction of the promoter activity.
Molecular epidemiological study of hepatitis B virus infection in two different ethnic populations from the Solomon Islands.
Abstract: While the prevalence of the BCP mutation (T(1762)A(1764)) tended to be higher in HBV/C, that of the Pre-C mutation (T(1846)) was significantly higher in HBV/D (P < 0.0001).
Clinical outcome and virological characteristics of hepatitis B-related acute liver failure in the United States.
Abstract: Prevalence of HBV genotypes, precore stop (G1896A) and core promoter dual (T1762A, A1764T) variants among patients with HBV-ALF were compared with a cohort of 530 patients with chronic HBV infection.
HBV mutation literature information.
PMID: 
2019
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