literature

High prevalence of hepatitis B virus genotype C/C1 in the Minangkabau ethnic group in Indonesia.

PMID: 23336976 2013 Virology journal

Abstract: The basal core promoter (BCP) region was amplified and directly sequenced to analyze T1753V and A1762T/G1764A mutations.

Abstract: The aim of this study was to assess the HBV genotype distribution pattern and the prevalence of pre-S, T1753V and A1762T/G1764A mutations among the Minangkabau HBV carriers.

Abstract: The prevalence of pre-S mutations, including both the pre-S deletion and pre-S2 start codon mutation, was 41.0%, and the T1753V and A1762T/

PMID: 23104706 2013 Annals of surgical oncology

Abstract: RESULTS: The genomic changes such as the G1896A at precore, the A1762T/G1764A at BCP, the C1653T and the T1753V at X gene, and pre-S2 deletion were not significantly associated with postoperative recurrence of HCC or survival of patients after curative resection.

Introduction: The X gene mutations (two of the most common being C1653T and T1753V) and pre-S2 gene deletions have been associated with increased incidence of

PMID: 22675557 2012 PloS one

Abstract: Similar correlation existed between BCP double mutation A1762T/G1764A, T1753V, C1653T and HCC.

Introduction: Those mutations include G1613A, C1653T in the EnhII region; T1753V, the double mutation A1762T/G1764A at the BCP region, G1896A and G1899A in the precore region.

Introduction: To illuminate the controversy, a related meta-analysis was performed and demonstrated

Mutations within enhancer II and BCP regions of hepatitis B virus in relation to advanced liver diseases in patients infected with subgenotype B3 in Indonesia.

PMID: 22095534 2012 Journal of medical virology

Abstract: Multivariate analysis showed that, in patients older than 45 years, C1638T and T1753V mutations constituted independent risk factors for the advancement of liver diseases.

Abstract: The presence of C1638T and T1753V mutations may serve as predictive markers for the progression of liver diseases in Indonesia and other countries, where subgenotype B3 infection is prevalent.

Mutational complex genotype of the hepatitis B virus X /precore regions as a novel predictive marker for hepatocellular carcinoma.

PMID: 22136288 2012 Cancer science

Abstract: Eight high-frequency mutations (G1613A, C1653T, T1753V, A1762T, G1764A, A1846T, G1896A and G1899A) were significantly associated with HCC.

Abstract: Whereas C1653T, T1753V, G1764A and A1846T were independent mutational factors for HCC, the significance of these individual mutations was negligible when analyzed with all clinico-virological variables.

A multicentre molecular analysis of hepatitis B and blood-borne virus coinfections in Viet Nam.

PMID: 22720022 2012 PloS one

Discussion: Genetic mutations and deletions in the pre-S and basal core promoter regions of the HBV genome including T1753V, A1762T, G1764A, and C1766T have been associated with more severe liver disease and the development of HCC.

Hepatitis B virus gene mutations in liver diseases: a report from New Delhi.

PMID: 22720023 2012 PloS one

Discussion: In contrast, analysis of sera or plasma from Japanese subjects with AC, CH, LC and HCC infected with HBV genotype C showed that the percentage of T1753V mutation increased with progression of liver disease [Takahashi et al., 1999].

Discussion: It is also reported that T1753V mutation was higher in HCC (53.2%) compared with LC (18.8%) and CH (9.8%).

Discussion: The T1762/A1764 and T1753V mutations in BCP could be one of the indicators for progression of

PMID: 22962577 2012 PloS one

Result: As expected, the frequencies of C1653T, T1753V, A1762T/G1764A mutations in these 'free' HBV DNAs from both tumor derived and non-tumor derived samples were at the same level as that for the serum derived samples of the LC group and HCC group (Table 2).

Result: Meta-analysis of previously published data, both our own and that of others, has shown that the number of mutations of the HBV genome (C1653T, T1753V and A1762T/G1764A) gradually increased with disease progression and correlated with hepatocarcinogenesis (Table 2).

Result: The frequencies of C1653T

Effects of antiviral therapy on the recurrence of hepatocellular carcinoma after curative resection or liver transplantation.

PMID: 23166535 2012 Hepatitis monthly

Introduction: C1653T, T1753V, A1762T/G1764A, T1674C/G, C1766T/T1768A, T53C, preS2 start codon mutation, preS1 deletion, C2964A, A2962G, C3116T, C7A, and their combinations are HBV mutations that are significantly associated with an increased risk of HCC occurrence.

[Analysis of the relationship between hepatitis B virus precore and basal core promoter mutations and acute-on-chronic liver failure].

PMID: 23207226 2012 Zhonghua gan zang bing za zhi

Abstract: Mutations G1899A, T1753V, and A1846T were correlated with disease recovery.

Abstract: Single mutations (A1762T, G1764A, T1753V, G1896A, and G1899A) and combined mutations (A1762T + G1764A, G1896A + G1899A, T1753V+ A1762T + G1764A, G1896A + G1899A + A1762T + G1764A, and

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