Clinical relevance and public health significance of hepatitis B virus genomic variations.
PMID: 19998495
2009
World journal of gastroenterology
Abstract: PreS deletions, C1653T, T1753V, and A1762T/G1764A are associated with an increased risk of HCC.
Hepatitis B virus subgenotypes and basal core promoter mutations in Indonesia.
PMID: 19705499
2009
World journal of gastroenterology
Abstract: Mutations in BCP, such as A1762T/G1764A and T1753V, might have an association with manifestations of liver disease.
Abstract: The T1753V was also higher in LC (46.8%), but lower in HCC (22.9%) and CH (18.0%), suggesting that this mutation may be an indicator of cirrhosis.
Hepatitis B virus genotypes/subgenotypes in voluntary blood donors in Makassar, South Sulawesi, Indonesia.
Abstract: A1762T/G1764A mutation was observed in 1.96% and 5.36%, whereas T1753V mutation was found in 2.94% and 1.79% of HBV/B and HBV/C, respectively.
Discussion: In our previous study, we included 15 HBV-associated liver disease samples from Makassar, and found that the prevalence of T1753V and A1762T/G1764A mutations were 40.0% and 60.0%, respectively, suggesting that those mutations were associated with severity of liver disease.
Discussion: Since both T1753V and A1762T/G1764A mutations were less common in blood donors, the chance of developing severe PMID: 19574418
2009
Journal of the National Cancer Institute
Result: C1653T in HBV subgenotype C2 and T1753V and A1762T/G1764A in HBV subgenotypes C1 and C2 were statistically significantly associated with an increased risk of HCC.
Result: Egger's test suggested no statistically significant publication bias for the studies of C1653T, T1753V, A1762T/G1764A, C1858T, and G1896A.
Result: Finally, we evaluated the frequencies of PreS mutations, C1653T, T1753V, and A1762T/ PMID: 18844615
2008
The American journal of gastroenterology
Introduction: The common precore mutation (G1896A), mutations in enhancer II (C1653T) and the basal core promoter (T1753V and the double mutations, A1762T, G1764A), and deletions in the pre-S region have been reported to be associated with the development of HCC.
Result: The total prevalence of the C1653T mutation from cases and controls is 20% (12/60) and that of T1753V is 28.4% (29/102) (Table 6).
Discussion: Furthermore, the C1653T and T1753V muta
A weak association between occult HBV infection and non-B non-C hepatocellular carcinoma in Japan.
Abstract: In the NBNC-HCC group, the determined nucleotide sequences of the enhancer II/core promoter/precore/core region did not contain any HCC-associated mutations, whereas 25 of 30 patients in the HBV-HCC group carried strains with C1653T, T1753V, and/or A1762T/G1764A mutations.
HBV mutation literature information.
PMID: 
2009
World journal of gastroenterology
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