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 HBV mutation literature information.


  Hepatitis B virus genotype, mutations, human leukocyte antigen polymorphisms and their interactions in hepatocellular carcinoma: a multi-centre case-control study.
 PMID: 26568165       2015       Scientific reports
Method: A risk prediction model to classify the HCC cases and controls was constructed according to the following steps: (1) Prediction factor selection: HBV genotype, the 11 independent HCC-related mutations (C1653T, C1673T, T1674C/G, C1730G, A1752G, T1753C, A1762T, G1764A, G1899A, G1915A/C and C1969T), the HLA SNPs (rs9272105 and rs9275319), the HCC-related multiplicative interactions (rs9272105 with the HBV genotype,


  Entecavir vs. lamivudine in chronic hepatitis B patients with severe acute exacerbation and hepatic decompensation.
 PMID: 24583247       2014       Journal of hepatology
Abstract: The T1753C/A mutation was also an independent predictor associated with overall and liver-related mortality at week 24.


  Molecular characterization of HBV strains circulating among the treatment-naive HIV/HBV co-infected patients of eastern India.
 PMID: 24587360       2014       PloS one
Result: In 4 cases it occurred together with the T1753C mutation whereas in 5 cases the BCP mutations were accompanied by the G1896A precore mutation.


  Significance of mutations in hepatitis B virus X gene for the pathogenesis of HB-associated glomerulonephritis.
 PMID: 25283864       2014       Acta virologica
Abstract: In HBV-GN patients, missense nucleotide mutations of C1653T, A1726C, A1727T, C1730G, T1753C, A1762T, and G1764A were detected in 84% of subjects, all located in the trans-acting regulatory region of the X gene.


  Novel point and combo-mutations in the genome of hepatitis B virus-genotype D: characterization and impact on liver disease progression to hepatocellular carcinoma.
 PMID: 25333524       2014       PloS one
Abstract: BCP_T1753C, core_T147C, surface_L213I had contributed significantly in the disease progression to HCC (p < 0.05) in HBeAg positive patients whereas precore_T1858C, core_I116L, core_P130Q and preS1_S98T in HBeAg negative patients.
Result: immune epitopes of HBx ORF was significantly altered with progression of  PMID: 23886144       2013       Asian Pacific journal of cancer prevention
Abstract: The prevalences of T1753C/A/G and A1762T/G1764A mutations in the basal core promotor (BCP) region were significantly higher in the HCC group compared to the non-HCC group.


  Hepatitis B virus subgenotype C2- and B2-associated mutation patterns may be responsible for liver cirrhosis and hepatocellular carcinoma, respectively.
 PMID: 23903686       2013       Brazilian journal of medical and biological research
Abstract: Multivariate regression analyses showed that HBV subgenotype C2 and C2-associated mutation patterns (C1653T, T1753C, A1762T, and G1764A) were independent risk factors for LC when CHB was the control, and that B2-associated mutation patterns (C1810T, A1846T, G1862T, and G1896A) were independent risk factors for HCC when LC was the control.
Abstract: Seven mutation patterns (C1653T, G1719T,


  Association of Hepatitis B Virus Mutations of A1846T and C1913A/G With Acute-on-Chronic Liver Failure Development From Different Underlying Chronic Liver Diseases.
 PMID: 24282424       2013       Hepatitis monthly
Table: T1753C/A


  Hepatitis B virus gene mutations in liver diseases: a report from New Delhi.
 PMID: 22720023       2012       PloS one
Table: T1753C/G


  HBV Subgenotype C2 Infection, A1762T/G1764A Mutations May Contribute To Hepatocellular Carcinoma with Cirrhosis in Southeast China.
 PMID: 23304671       2012       Iranian journal of public health
Introduction: HBV mutations were often observed in the pre-C and basal core promoter (BCP) regions, such as T1753C, A1762T, G1764A, G1862T, G1896A and G1899A nucleotide acid substitution.



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