Molecular characterization of hepatitis B virus (HBV) isolates, including identification of a novel recombinant, in patients with acute HBV infection attending an Irish hospital.
Abstract: A triple mutation, T1753C/A1762T/G1764A was identified in only one isolate (Irish-3) associated with severe infection.
Initial load of hepatitis B virus (HBV), its changing profile, and precore/core promoter mutations correlate with the severity and outcome of acute HBV infection.
Abstract: In univariate analysis, seronegativity for hepatitis B envelope antigen (HBeAg) and mutations in both the precore (G1896A and/or G1899A) and core promoter (T1753A/C and/or T1754C/G and/or A1762T/G1764A) were associated with FH (odds ratio [OR], 5.60; P=0.0269 and OR, 52.0; P=0.0006; respectively).
Genotype and variations in core promoter and pre-core regions are related to progression of disease in HBV-infected patients from Northern Vietnam.
PMID: 17203204
2007
International journal of molecular medicine
Abstract: The triple mutation T1753C/A1762T/ G1764A was quite common and was more prevalent in LC and HCC than in CH and ASC.
Association of core promoter/precore mutations and viral load in e antigen-negative chronic hepatitis B patients.
Abstract: Triple core promoter mutations T1753C/A1762T/G1764A [corrected] appeared to be linked to genotype C rather than genotype B HBV (19.2%vs 1.9%; P = 0.013).
[Core promoter mutations of HBV isolated from patients with chronic hepatitis B in Guangxi].
Abstract: A --> G at nt1752 (resulting in isoleucine to valine) was seen in 37.1% (13/35) of the HBV DNA positive patients, and T --> C at nt1753 was seen in 20% (7/35).
Genome replication, virion secretion, and e antigen expression of naturally occurring hepatitis B virus core promoter mutants.
Abstract: All had 1762/1764 mutations and an additional substitution at position 1753 (T to C), at position 1766 (C to T), or both.
Sequential analysis of hepatitis B virus core promoter and precore regions in cancer survivor patients with chronic hepatitis B before, during and after interferon treatment.
Abstract: Five of the six (83%) responders displayed the double CP mutation A1762T/G1764A always in association with a T1753C change.
[Hepatitis B virus gene mutations in the sera of three patients with coexisting hepatitis B surface antigen and anti-surface antibody].
PMID: 10804824
2000
Rinsho byori. The Japanese journal of clinical pathology
Abstract: Case 1 possessed a point mutation, T to C at nucleotide position 1753, in the region overlapping the coding region of the X gene and the CCAAT/enhancer binding protein(C/EBP) binding region within the core promoter region.
Prevalence of mutations in core promoter/precore region in Japanese patients with chronic hepatitis B virus infection.
PMID: 9824137
1998
Digestive diseases and sciences
Abstract: Furthermore, a mutation at nucleotide 1753 from T to C or G was frequently found in anti-HBe positive patients and was often accompanied by the double mutation.
HBV mutation literature information.
PMID: 
2008
Journal of medical virology
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