literature

HBV mutation literature information.

Frequency and clinical significance of core promoter and precore region mutations in Tunisian patients infected chronically with hepatitis B.

PMID: 22997074 2012 Journal of medical virology

Abstract: A1679G/C, T1753C/G/A, A1762T/G and A1762T-G1764A were more prevalent in older patients.

Hepatitis B virus core promoter mutations contribute to hepatocarcinogenesis by deregulating SKP2 and its target, p21.

PMID: 21704589 2011 Gastroenterology

Abstract: METHODS: We constructed a series of HBx mutants with changes in the CP region that correspond to A1762T/G1764A (TA), T1753A, T1768A, or a combination of these (combo) and expressed them, along with wild-type HBx under control of its endogenous promoter, in primary hu

Result: In addition to the TA mutant, we studied three HBx mutants in the genotype C background that corresponded to the following core promoter mutations: (1) T1753A, (2) T1768A, (3) combination of T1753A, TA, and T1768A (Combo mutant).

A case-control study on sequence variations in the enhancer II/core promoter/precore and X genes of hepatitis B virus in patients with hepatocellular carcinoma.

PMID: 21063480 2010 Hepatology international

Abstract: RESULTS: The prevalence of T1753C/A, A1762T/G1764A and G1899A mutations were significantly higher in the HCC group compared to the non-HCC group (43.3 vs.

Prevalent HBV point mutations and mutation combinations at BCP/preC region and their association with liver disease progression.

PMID: 20846420 2010 BMC infectious diseases

Abstract: The top three multi-mutations were A1762T/G1764A (36%), A1762T/G1764A/G1896A (11%) and T1753(A/C)/A1762T/G1764A/G1896A (8%).

Result: In univariate binary logistic regression analysis, all the top five high occurrence mutations seemed to relate to ALD

Discussion: A feature of those mutations, including T1753A/C, G1764A and A1762T, is their significance as risk factors in disease progression only shown by univariate analysis but not in the multivairate model when patient age was considered.

Hepatitis B virus genotype and basal core promoter/precore mutations are associated with hepatitis B-related acute-on-chronic liver failure without pre-existing liver cirrhosis.

PMID: 20070500 2010 Journal of viral hepatitis

Table: T1753C/A

Chimeric constructs between two hepatitis B virus genomes confirm transcriptional impact of core promoter mutations and reveal multiple effects of core gene mutations.

PMID: 19327810 2009 Virology

Discussion: The high replication capacity was mapped to nucleotides 1574-1986, where 7 core promoter mutations are present: G1751T, T1753A, G1757A, A1762T, G1764A, C1766T, and T1768A.

HBV A1762T, G1764A mutations are a valuable biomarker for identifying a subset of male HBsAg carriers at extremely high risk of hepatocellular carcinoma: a prospective study.

PMID: 18844615 2008 The American journal of gastroenterology

Result: Mutations at nucleotide (nt) 1653 from C to T and nt 1753 from T to A, G or C (T to V) have been reported to be associated with severe chronic hepatitis B and the development of cirrhosis and HCC.

Initial load of hepatitis B virus (HBV), its changing profile, and precore/core promoter mutations correlate with the severity and outcome of acute HBV infection.

PMID: 17380283 2007 Journal of gastroenterology

Abstract: In univariate analysis, seronegativity for hepatitis B envelope antigen (HBeAg) and mutations in both the precore (G1896A and/or G1899A) and core promoter (T1753A/C and/or T1754C/G and/or A1762T/G1764A) were associated with FH (odds ratio [OR], 5.60; P=0.0269 and OR, 52.0; P=0.0006; respectively).

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