Abstract: A high-frequency mutation, T1719G (93.3%), was detected in the BCP/PC region, which reduced the viral replication.
Result: Twenty-one mutations were identified in the core upstream regulatory sequence (nt1678-1741) from 16 samples, and T1719G occurred in 93.8% (15/16) samples.
Table: T1719G
Discussion: Fifteen cases of T1719G mutations in the BCP/PC region were identified in 16 samples in the present study, which can inhibit in vitro HBV replication, and may lead to a low HBV DNA viral load.
HBV T1719G mutation reduced HBV replication through mutant Enh II and HBx protein in vitro.
Abstract: And such reduction caused by T1719G mutation could be rescued by HBx protein.
Abstract: In this study, we aimed to evaluate the function and mechanisms of the T1719G mutation on viral replication capacity.
Abstract: It was repeatedly reported that the hepatitis B virus (HBV) T1719G mutation was very common and related to progression and malignancy of liver disease.
Abstract: Our results show that the T1719G mutation decreases HBV viral replication capacity possibly by mutant HBx protein and altered Enh II activity.
Abstract: Our results showed that the T1719G mutation impaired viral replication efficacy compared with the wild type both by reducing
Complete genome sequencing and clinical analysis of intrahepatic hepatitis B virus cccDNA from HCC.
HBV mutation literature information.
PMID: 
2021
BMC infectious diseases
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