Conclusion: In conclusion, antigenic index analysis and de novo prediction of tertiary conformation of the three HBsAg variants (T123A, M133L, and T143M) found in Indonesian blood donor samples with undetectable HBsAg revealed that T143M substitution altered the antigenicity most significantly compared to the other two mutation patterns and the other known variants.
Result: The pattern T143M, on the other hand, besides showing differentially-oriented side chain of Met, also sho
Table: T143M
Figure: Tertiary structure prediction of M54923 (reference sequence), T123A, M133L, and T143M mutants.
Occult hepatitis B in blood donors in Indonesia: altered antigenicity of the hepatitis B virus surface protein.
Abstract: Seven of the viremic samples had nucleotide substitutions (A521G, A551T, C582T, and A562G) in the S gene, causing amino acid mutations (T123A, M133L, and T143M) in the 'a' determinant of HBsAg that resulted in changes in the predicted antigenicity.
Expression of Hepatitis B virus surface antigen (HBsAg) from genotypes A, D and F and influence of amino acid variations related or not to genotypes on HBsAg detection.
PMID: 20231988
2009
The Brazilian journal of infectious diseases
Abstract: However, the presence of two single variations, T143M in genotype A, and T125M in genotype D, produced a decrease of 44% and an increase of 34%, respectively, on HBsAg mean values in comparison with their consensus forms.
Abstract: However, unique amino acid substitutions not linked to genotypes, such as T125M and T143M described here, should have more implications in HBV immunological diagnostics than the set of variations characteristic of each HBV genotype.
[The analysis of hepatitis B virus genetic characterization from immuned children and their mother].
PMID: 20104776
2009
Zhonghua shi yan he lin chuang bing du xue za zhi
Abstract: Gene of twins has mutation of T143M.
Hepatitis B virus genotypes and hepatitis B surface antigen mutations in family contacts of hepatitis B virus infected patients with occult hepatitis B virus infection.
PMID: 19207682
2009
Journal of gastroenterology and hepatology
Abstract: A128V & T143M mutations were observed in 5 of 13 (38.4%) subjects and A128V & P127S in 2 of 13 (15.3%) patients (P = 0.385).
Abstract: A128V mutation was seen in two (15.3%) subjects with D2 genotype, while T143M mutation was seen in three (23.07%) subjects with A1genotype.
[Algorithm of serologic screening and assessment of prevalence of serologically meaningful mutations of HBsAg in hepatitis B virus carriers].
PMID: 18283732
2007
Zhurnal mikrobiologii, epidemiologii i immunobiologii
Abstract: Analysis of primary nucleotide sequence revealed serologically meaningful mutations in S-gene of HBV in all 9 isolates: 3 of them contained substitution mutation G145R, 5--S143L, and one--T143M.
Abstract: Prevalence of HBsAg mutations in HBV carriers with high level of HBsAg was assessed for the first time: prevalence of G145R, S143L/T143M mutations, and all serologically atypical variants was 0.12%, 0.24%, and 0.76% respectively.
Transmission of G145R mutant of HBV to an unrelated contact.
Abstract: Mutant G145R along with T118V and T143M was identified in three subjects who included one 1 degrees, one 2 degrees, and one 3 degrees contact.
Abstract: Presence of T118V and T143M mutations along with G145R mutation in these subjects provides an indirect evidence for the possible horizontal transmission of G145R HBV variant to a 3 degrees unrelated contact.
Molecular epidemiology and transmission of hepatitis B virus in close family contacts of HBV-related chronic liver disease patients.
HBV mutation literature information.
PMID: 
2010
Virology journal
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