Method: We also considered eight VEMs (C139S, S/T140I, P142S, S/T143L/M, D144A/E/G/N, G145A/E/R, K141A/I/R and C147S) which are located within the epitope region neutralized by the HBV vaccine (aa139-147).
Result: Other VEMs that had an overall prevalence of >1% were T118A/R/V, M133I/L/T, A128V, Q129H/N/R, G145A/R, P120S/T and S/T143L/M
Molecular characteristics of HBV infection among blood donors tested HBsAg reactive in a single ELISA test in southern China.
8Discussion: Mutations in the MHR and non-MHR in the S region, such as Y100C, Y103I, Q129H, T131I, M133L/S/T, F134L, T143M, G145R, and L175S, were found in this study, and could reduce the affinity of monoclonal antibodies for ""a"" epitopes by altering the structure of HBsAg protein, which may contribute to the failure of commercial reagents."
Result: Several mutations associated with the interference of HBsAg detection, such as mutations in the major hydrophilic region (MHR), including Q129H, T131
Patterns of hepatitis B virus S gene escape mutants and reverse transcriptase mutations among genotype D isolates in Jordan.
Discussion: In Turkey, the most frequent mutations observed were T143M and K122R, whereas in Egypt 14.8% presented with mutations in the MHR, and eight different mutations were discovered: R122K, S143L, L109P, S114P, S117N, P127S, P127T and Y134F.
Analysis of HBV basal core promoter/precore gene variability in patients with HBV drug resistance and HIV co-infection in Northwest Ethiopia.
Abstract: Recognized mutations associated with HBsAg detection and/or vaccination failure, T140I, T143S/M, G145R, and Y161F, were identified in 20 subjects; while mutations linked to HBeAg-defective variants, PC G1896A and BCP A1762T/G1764A, were found in 7 and 11 subjects, respectively.
HIV therapy with unknown HBV status is responsible for higher rate of HBV genome variability in Ethiopia.
Abstract: In particular, the 'a' determinant surface gene mutations (sT125S, sA128V, sQ129H/R, sT131I, sC137S, sT143M, sD144D/E, sG145R, sT148P) and the majority of clustered/multiple as well as drug selected immune escape HBsAg mutations were more prevalent
Molecular epidemiology of hepatitis B virus isolated from Bangladesh.
Abstract: A significant number of mutations (Thr118Val
Result: Several mutations were observed in 'a' determinant region of S gene such as, T118V, T125M, T126I, P127T, A128V and T/S143L/M according to different genotypes of HBV (Table 1).
Discussion: Among which, Thr118Val, Thr125Met, Pro127Thr, Ala128Val and Thr/Ser143Leu/Met were observed in genotype D sequences, which is thought to have strong impacts on functions of S gene.
Molecular epidemiology and genotyping of hepatitis B virus of HBsAg-positive patients in Oman.
8Discussion: The identified sT/S143L/M mutations of the HBsAg gene, mapped to loop 2 of the ""a"" determinant, and were thought to be associated with vaccination allowing ongoing replication of HBV."
Discussion: We found the sP120T, sT126S, sM133T, and sT/S143L/M mutations in the HBsAg-positive patients while these mutations have been previously described as possible vaccine escape mutations (reviewed in:).
Hepatitis B surface antigen variants in voluntary blood donors in Nanjing, China.
HBV mutation literature information.
PMID: 
2022
PloS one
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