Discussion: Thirteen MHR mutations (G119R, P120T, C124R, C124Y, I126S, Q129R, S136P, C139R, T140I, K141E, D144A, G145A, and G145R) were detected and functionally characterized in vitro and in vivo.
Hepatitis B surface gene 145 mutant as a minor population in hepatitis B virus carriers.
Result: In addition, I/T126S (n = 4), I/T126V (n = 1), Q129L (n = 1), T131P (n = 2), M133T + T140I (n = 1), and S136Y (n = 1) mutants were detected as a predominant strain in 10 (9.3%) of the 107 HBV carriers who had not received the HB vaccine or HBIG.
Discussion: Direct sequencing showed that I/T126S, I/T126V, Q129L, T131P, M133T + T140I, and S136Y mutants were present as a predominant strain in 107 HBV carriers.
Influence of mutations in hepatitis B virus surface protein on viral antigenicity and phenotype in occult HBV strains from blood donors.
Abstract: Four out of the 13 mutations (C124R, C124Y, K141E, and D144A) strongly decreased the analytical sensitivity of seven commercial HBsAg immunoassays, and 10 (G119R, C124Y, I126S, Q129R, S136P, C139R, T140I, K141E, D144A, and G145R) significantly impaired virion and/or S protein secretion in both HuH7 cells and mice.
[Analysis on mutation of S gene and P gene of hepatitis B virus in two counties of Sichuan Province].
Abstract: RESULTS: Of 47 serum samples from patients with chronic HBV infection, amino acid mutation in 'a' determinant occurred in 12 samples (25.53%,12/47), correlating with T126A, I126T/S, P127T, T131N, M133L, M133T and T140I; high proportion of mutation clustered in first loop of 'a' determinant (92.86%,13/14), rtV207I mutation in C domain of reverse transcription occured in one sample.
Detection of hepatitis B virus surface antigen mutants in paraffin-embedded hepatocellular carcinoma tissues.
1Abstract: Mutations on the ""a"" determinant (Thr126Ser, Gly145Arg, a double mutant Thr126Ser/Gln129Asn, Met 133Leu and Thr140Ile) were identified in 5 samples while the wild type sequence was found in 2 others."
HBV mutation literature information.
PMID: 
2014
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