literature

HBV mutation literature information.

Prevalence and significance of Hepatitis B reverse transcriptase mutants in different disease stages of untreated patients.

PMID: 22882650 2012 Liver international

Discussion: Due to the overlapping structure of HBV genomes, the most of RT-HBsAg concomitant mutations were found centered in the A-B interdomain, corresponding to the overlapping 'a' determinant with a cluster of affirmed immune-escape mutations, such as s126A/N/S, sT131N and sG145R.

Hepatitis B surface antigen variants in voluntary blood donors in Nanjing, China.

PMID: 22500577 2012 Virology journal

Result: D99N, Q101R/H, L109I, I110N, T115S, S117T, P120S, K122R, S126T/A, P127H, A128V, Q129R/H/L, G130E, T131N/A, M133T/L/S, F134R/I/L, T143M, A159V, F161Y, W163G, E164G, V168A

Role of hepatitis B virus genetic barrier in drug-resistance and immune-escape development.

PMID: 21831732 2011 Digestive and liver disease

Abstract: Vaccine-escape associated sT131N-mutation is a natural polymorphism in both A and G genotypes.

A novel nucleotide insertion in S gene of hepatitis B virus in a chronic carrier.

PMID: 20492719 2010 Virology journal

Abstract: S114T, C121Y, T126S/A, Q129K, G130R, T131N, M133T, G145R, N146D substitution and premature stop codon were also found in those clones.

Result: Of 4 clones with wildtype HBsAg, T131N(ACC AAC) and M133T(ATG ACG) substitution occurred in clon17-clone19, also forming a possible N-Linked glycosylation site(figure 2).

Hepatitis B viral surface mutations in patients with adefovir resistant chronic hepatitis B with A181T/V polymerase mutations.

PMID: 20119580 2010 Journal of Korean medical science

Introduction: In this patient, they detected deletions of nucleotides 23 to 55 (amino acids 12 to 22) in the Pre-S2 region, and amino acid substitutions at I126S, T131N, M133T, and S136Y in the 'a' determinant region of HBsAg.

[Analysis on mutation of S gene and P gene of hepatitis B virus in two counties of Sichuan Province].

PMID: 20077675 2009 Zhongguo yi miao he mian yi

Abstract: RESULTS: Of 47 serum samples from patients with chronic HBV infection, amino acid mutation in 'a' determinant occurred in 12 samples (25.53%,12/47), correlating with T126A, I126T/S, P127T, T131N, M133L, M133T and T140I; high proportion of mutation clustered in first loop of 'a' determinant (92.86%,13/14), rtV207I mutation in C domain of reverse transcription occured in one sample.

Prevalence of occult hepatitis B virus infection in a general adult population in Korea.

PMID: 19401629 2009 Intervirology

Abstract: Sequencing of HBV S gene in 3 cases revealed one wild-type and two mutant strains (W74S, F85Y; T63I, W74S, T131N substitutions).

[A study on mutations of the overlapping hepatitis B virus surface and polymerase gene in patients with HBV reinfection after liver transplantations].

PMID: 18423147 2008 Zhonghua gan zang bing za zhi

Abstract: Mutations were detected as I126S, T131N, S143T and G145R in 'a' determinant and L110F, I113S, T160K in up- or down-stream of 'a' determinant.

Overlapping gene mutations of hepatitis B virus in a chronic hepatitis B patient with hepatitis B surface antigen loss during lamivudine therapy.

PMID: 15953865 2005 Journal of Korean medical science

Abstract: Sequencing of the 'a' determinant revealed amino acid substitutions as I126S, T131N, M133T, and S136Y.

Result: These changes were consistent with amino acid substitutions at position I126S, T131N, M133T, and S136Y.

Browser Board

Co-occurred Entities

Filtrator