literature

HBV mutation literature information.

Hepatitis B genotypes and surface antigen mutants present in Pakistani blood donors.

PMID: 28582431 2017 PloS one

Result: Finally 15 strains had mutations outside of E1 and E2; Y100C plus Q129R (n = 1), L109LR (n = 1), T126S (n = 1), T126TS (n = 1), A128V (n = 1), Q129H (n = 1), Q129QH (n = 1), G130R (n = 1), G130R, T131N and M133T (n = 1), T131N (n = 1)

Result: Those omitted included R122K which is the determinant for subtyping HBsAg as ad versus ay, T126I for genotype C, A128V for genotype D2, and T131N for genotype A1.

Table: T131N

Occult HBV among Anti-HBc Alone: Mutation Analysis of an HBV Surface Gene and Pre-S Gene.

PMID: 28332361 2017 Yonsei medical journal

Discussion: The 'a' determinant mutations found in this study were I126M/N, P127S/T, T131N, S132F, M133T, F134L/T, D144E, and G145A.

HBV genotypes and drug resistance mutations in antiretroviral treatment-naive and treatment-experienced HBV-HIV-coinfected patients.

PMID: 27167598 2017 Antiviral therapy

Method: The sequences were examined for known vaccine escape mutations (sG145R/A, sP142S, sI/T126A/N/I/S,

Result: Additional immunoprophylaxis mutations were observed in patients 224E (sI110L), 080N (sT131N), and 132E (sM133T).

Result: Four (6.35%) patients - 006N, 040N, 125E, and 218E - had both sT131N and sS143T mutations.

Characterization of hepatitis B virus (HBV) preS/S gene mutations in blood donors with occult HBV infection in the Baoji area of North China.

PMID: 28236303 2017 Transfusion

Abstract: Specifically, the incidence of five OBI-related major hydrophilic region mutations (sS117T, sT118K, sT131N, sT134Y/L, and sD144E) was significantly higher in blood donors with OBI than in controls.

Molecular epidemiology of hepatitis B virus isolated from Bangladesh.

PMID: 27652086 2016 SpringerPlus

Abstract: A significant number of mutations (Thr118Val, Thr125Met, Thr126Ile, Pro127Thr, Ala128Val, Thr131Asn/Ser, Thr/Ser143Leu/Met) were found in 'a' determinant region which may admit resistance to the available vaccines and failure of HBsAg detection.

Discussion: Furthermore, Sequences of genotype C were found to have Thr126Ile and Thr131Ser mutations, and genotype A sequences have only Thr131Asn mutation in 'a' determinant region.

Serologic and genotypic characterization of hepatitis B virus in HIV-1 infected patients from South West and Littoral Regions of Cameroon.

PMID: 27769271 2016 Virology journal

Abstract: Escape mutations associated with failure of diagnosis (Y100C, R122K and Q129H) and with vaccine escape (Q129R and T131N) were detected in varying frequencies in the population.

Table: T131N

Discussion: There were three escape mutations identified which were previously associated with diagnostic failure (Y100C, R122K and Q129H) and two associated with vaccine escape (Q129H and T131N).

Overt and occult hepatitis B virus infection among treatment-naive HIV-infected patients in Brazil.

PMID: 27061406 2016 Journal of medical virology

Abstract: Sequencing of the S gene revealed Y100C, T131N, and D144A mutations.

Occult HBV Infection May Be Transmitted through Close Contact and Manifest as an Overt Infection.

PMID: 26457811 2015 PloS one

Result: Amino acid substitution mutations in the major hydrophilic region predicted from eleven clones of HBV from the mother's sample include D99N, T131N, F161S and V168A.

Result: Amino acid substitutions in the major hydrophilic region predicted from twelve clones of HBV from the father's sample include T115I, T116A, S117G, T118K, 123N, Q129L, T131N, M133L, M133S, F134L,

Discussion: The remaining two also have detection escape mutations (T131N and M133L).

Impact of HBV genotypes A and D genetic variability on infection evolution.

PMID: 25989376 2015 Infection, genetics and evolution

1Abstract: Mutations associated with immune-escape (T131N, D144A/E, G145K), amino acid polymorphisms in ""a determinant"" domain of S protein and mutations/deletions in preC/C region were found in isolates from acute and chronic hepatitis B cases."

Seroepidemiology and occult hepatitis B virus infection in young adults in Banjarmasin, Indonesia.

PMID: 25521058 2015 Journal of medical virology

Abstract: Thirteen amino acid substitutions were identified: T126S, P127S, Q129R, T131N, M133T, and Y161S in the HBsAg-positive group; P120T, T126I, G145S, Y161F, E164V, and V168F in the occult-HBV group; and T143S in both groups.

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