"Occult Hepatitis B Virus Infection in Maintenance Hemodialysis Patients: Prevalence and Mutations in ""a"" Determinant."
PMID: 32922195
2020
International journal of medical sciences
1Abstract: By sequencing analysis, we revealed mutations at the ""a"" determinant of HBsAg, including Q129R, T131N, M133S, F134L and D144E."
5Result: However, patient No.6 was found to have mutations of Gln129Arg (Q129R), Thr131Asn (T131N), Met133Ser (M133S), Phe134Leu (F134L) and Asp144Glu (D144E) in the ""a"" determinant of HBsAg (Figure 2, Table 3)."
8Discussion: According to the repor
A Hyper-Glycosylation of HBV Surface Antigen Correlates with HBsAg-Negativity at Immunosuppression-Driven HBV Reactivation in Vivo and Hinders HBsAg Recognition in Vitro.
Method: The following mutations associated with additional N-linked glycosylation sites were identified: 114N-ins, T115N, T117N, T123N, S113N+T1
Discussion: Considering the N-linked glycosylation sites observed in our study, recent studies have shown that the mutational profile T131N+M133T reduces HBsAg antigenicity and fails to induce anti-HBs response without altering HBV replicative capacity.
Discussion: Other studies have also shown the capability of T131N+M133T to rescue HBsAg secretion impaired by the vaccine escape mutation G145R.
Occult HBV infection in Chinese blood donors: role of N-glycosylation mutations and amino acid substitutions in S protein transmembrane domains.
Discussion: Mutations T116N, T123N, G130N, and T131N + M133 T have been reported to reduce antigenicity and immunogenicity and rescue virion secretion in N146 mutants.
Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression.
PMID: 29713126
2018
World journal of gastroenterology
Method: RT mutations rtN139K/T/H and rtM2
Method: Notably, these authors also found that RT mutations in the A-B interdomain could lead to simultaneous AA substitutions sI126A/N/S/, sG130N, sT131N/P, and sG145R of the overlapped 'a' determinant of HBsAg, including the most frequently described immune-escape mutation sG145R (1/192, 0.52%).
Mutations within the major hydrophilic region (MHR) of Hepatitis B virus from individuals with simultaneous HBsAg and anti-HBs in Guangzhou, Southern China.
Abstract: In addition, sQ101 K, sT131N, and sM133L were more frequently discovered in group I with significant difference (P < 0.05).
Amino acid substitutions Q129N and T131N/M133T in hepatitis B surface antigen (HBsAg) interfere with the immunogenicity of the corresponding HBsAg or viral replication ability.
Abstract: In our study, we aim to investigate biological significance of amino acid (aa) substitutions in HBsAg, Q129 N and T131 N/M133 T, for glycosylation, antigenicity and immunogenicity of variant HBsAg (vtHBsAg) and viral replication.
Abstract: Thus, we conclude that vtHBsAg with Q129 N or T131 N/M133 T creates new N-glycosylation and interferes with both the antigenicity and immunogenicity of vtHBsAg.
Abstract: vtHBsAg of Q129 N and T131 N/M133 T created ne
Immune-escape mutations and stop-codons in HBsAg develop in a large proportion of patients with chronic HBV infection exposed to anti-HBV drugs in Europe.
HBV mutation literature information.
PMID: 
2022
PloS one
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