Discussion: The other four mutations found in the a determinant-T126S, P127S, D144E, and G145R-are known escape mutants and were detected in five Palestinian D1 samples accounting for 12.5% of the total 40 samples.
Discussion: Two of these samples presented with the escape mutations D144E and G145R simultaneously, while the other three samples presented with one single escape mutation each; G145R, T126S, or P127S.
Molecular epidemiology and genotyping of hepatitis B virus of HBsAg-positive patients in Oman.
Result: Other possible vaccine escape mutations were detected at positions T126 (T126S) and M133 (M133T); however, their impact on vaccine escape is under discussion.
Table: T126I/S
Discussion: We found the sP120T, sT126S, sM133T, and sT/S143L/M mutations in the HBsAg-positive patients while these mutations have been previously described as possible vaccine escape mutations (reviewed in:).
Hepatitis B surface gene 145 mutant as a minor population in hepatitis B virus carriers.
Result: As a predominant strain, I/T126S mutant was detected in one (5.6%) of the 18 children with failure of prophylaxis.
Result: In addition, I/T126S (n = 4), I/T126V (n = 1), Q129L (n = 1), T131P (n = 2), M133T + T140I (n = 1), and S136Y (n = 1) mutants were detected as a predominant strain in 10 (9.3%) of the 107 HBV carriers who had not received the HB vaccine or HBIG.
Discussion: Among these mutants, the I/T126S mutant was the most frequent (4/107 = 4.7%) in the group 2 of the present study.
Discussion: Compared with the previous study, the frequency of I/T126S of the present study is high
Comprehensive analysis of the prevalence of hepatitis B virus escape mutations in the major hydrophilic region of surface antigen.
Abstract: Eight important mutations associated with diagnostic failure, P120T, T126S, Q129H, G130N, S143L, D144A, and G145A/R, were prevalent in one or more genotypes, with the frequency of no less than 1%.
[The panels of serums, containing various subtypes and mutant forms of HBsAg, to evaluate the diagnostics sensitivity of kits oa reagents detecting HBsAg].
Abstract: The testing of reagents kits to detect HBsAg using twi panels containing recombinant and native variants of HBsAg, demonstrated that these kits enable to detect various sero-vatriants of HBsAg (ayw2, adw2, ayw3varA, ayw3varB, adrq-) in concentration 0.1-0.01 IU/l and the so called elusive mutant forms of HBsAg of recombinant and native origin (G145R, Q129R, Q129H, Q129L, T143K, T126N, T126S, D144A, M133L, K141E and P142S).
Breakthrough HBV infection in vaccinated children in Taiwan: surveillance for HBV mutants.
Abstract: Among vaccinated individuals with breakthrough HBV infection, sG145R & sT126A/S mutations (which account for 48% of the mutants detected) have become prominent.
A novel nucleotide insertion in S gene of hepatitis B virus in a chronic carrier.
Abstract: S114T, C121Y, T126S/A, Q129K, G130R, T131N, M133T, G145R, N146D substitution and premature stop codon were also found in those clones.
Result: C121Y(TGC TAC), T126S/T126A(ACT TCT or ACT GCT), Q129K(CAA AAA), G130R(GGA AGA), G145R(GGA AGA) and other aa substitution compared with consensus sequence in MHR were also showed in figure 2.
Establishment of an HBsAg mixed titer performance panel and HBsAg working standard for quality control of HBsAg diagnostic kits in Korea.
Abstract: Interestingly, Thr123Ala and Gly145Arg were observed only in failure-group mothers, whereas Thr126Asn, Thr126Ser, Thr143Asn, Asp144Gly, and Asp144Ala were seen in the success group.
[Impact of amino acid sequence variation of a determinant(s) on the antigenic properties of hepatitis B virus HBsAg].
HBV mutation literature information.
PMID: 
2014
PloS one
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