literature

HBV mutation literature information.

Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.

PMID: 35390033 2022 PloS one

Table: T126N/I

Characterization of Antigen Escape Mutations in Chronic HBV-Infected Patients in Upper Egypt.

PMID: 34234472 2021 Infection and drug resistance

8Discussion: Several other studies reported other substitutions in the ""a"" determinant region and associated with vaccine escape, such as T116N, P120S/E, I/T126A/N/I/S, Q129H/R, M133L, K141E, and D144A/E."

Detection of Q129H Immune Escape Mutation in Apparently Healthy Hepatitis B Virus Carriers in Southwestern Nigeria.

PMID: 34210073 2021 Viruses

Introduction: In the following years, other mutations observed on the a-determinant, which are considered as immune escape variants, including T116N, P120S/E, I/T126A/N/I/S, Q129H/R, M133L, K141E, P142S, and D144A/E, have also been reported.

Investigation of immune escape-associated mutations of hepatitis B virus in patients harboring hepatitis B virus drug-resistance mutations.

PMID: 32994690 2020 World journal of gastroenterology

Result: In particular, mutations were detected in 67/63/168 of 298 sQ101H/K/R-positive patients, 39/2/76 of 117 sS114A/L/T-positive patients, 5/5/15/3/1/2 of 31 sT118A/K/M/R/S/V-positive patients, 3/0/0/23/81 of 107 sP120A/L/Q/S/T-positive patients, 94/58/0/214 of 366 sT/I126A/N/P/S-positive patients, 14/46/136 of 196 sM133I/L/T-positive patients, 1/8 of 9 sC137W/Y-positive patient

"Occult Hepatitis B Virus Infection in Maintenance Hemodialysis Patients: Prevalence and Mutations in ""a"" Determinant."

PMID: 32922195 2020 International journal of medical sciences

8Discussion: According to the reports, the ""a"" determinant of OBI patients contains Gly145Arg/Ala/Ile/Trp/Glu (G145R/A/I/W/E), Leu109Arg (L109R), Gly119Arg (G119R), Pro120Thr (P120T), Lys122Ile (K122I), Thr126Asn (T126N), Thr127Arg (T127R), Gln129Asn (Q129N), Thr131Asn (T131N

Prevalence of Potential Resistance Related Variants Among Chinese Chronic Hepatitis B Patients Not Receiving Nucleos(T)ide Analogues.

PMID: 32765014 2020 Infection and drug resistance

5Result: In the present study, the rt134 and rt153 variants led to the concomitant occurrence of ""a"" determinant mutations, including sT126A (n=5), sT126S (n=2), sT126N (n=1), and sG145R (n=1)."

In silico functional and structural characterization of hepatitis B virus PreS/S-gene in Iranian patients infected with chronic hepatitis B virus genotype D.

PMID: 32695898 2020 Heliyon

Conclusion: This research attempted to investigate several new substitution sites (T126N, N131T, P142L, and S207N) identified in two HBV S proteins.

Introduction: This study attempted to id

Result: The results of our amino acid sequences of the preS/S gene compared to consensus genes showed several mutations at position L109R, T113S, K122R, T126N, N131T, F134Y, P142L, W163R and R169P of the major hydrophilic region (MHR).

Molecular characterization of hepatitis B virus in blood donors in Botswana.

PMID: 30382563 2019 Virus genes

Result: Twelve mutations including diagnostic escape mutations (sY100C, sR122K, sT123A, sC124R, sM133T), vaccine escape mutations (sT126N, sQ129R, sM133L, sF134V) and immunoglobulin therapy failure (sG119R, sG130N,

PMID: 29859062 2018 BMC infectious diseases

Method: We determined the prevalence of 29 immune-associated escape mutations (sQ101K, sT114R, sP120S/T/A, sT123A/N, sT126N/S, sP127L, sA128V, sQ129R/N, sG130N/R, sT131I, sM133I/L/T,

Hepatitis B infection among HIV infected individuals in Gabon: Occult hepatitis B enhances HBV DNA prevalence.

PMID: 29315352 2018 PloS one

Method: In addition, we looked for Vaccine Escape Mutants (VEMs) and polymorphic mutations outside (Y100C, Q101H, S117N, T118R and P120S) and within the HBsAg immuno-dominant 'a' determinant (I/T126A/N, A128V, Q129H/R, G130N, M133L/T, K141E, S143L, D144A/H/E and G145R).

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