Method: The sequences were examined for known vaccine escape mutations (sG145R/A, sP142S, sI/T126A/N/I/S, sQ129H/R, sM133L, sD144A/E, sP120S/E, sK141E, sP134I, and sT116N), immunoprophylaxis escape mutations (
Prevalence of S gene mutations within the major hydrophilic region of hepatitis B virus in patients in Dongguan, southern China.
Abstract: In addition, sQ101K/R was found only in genotype C isolates (P < 0.05), and sT126A was only discovered in genotype B isolates (P = 0.047), indicating that such mutations were genotype-associated mutations.
Temporal trend of hepatitis B surface mutations in the post-immunization period: 9 years of surveillance (2005-2013) in eastern China.
8Discussion: Of the 11 positions where mutations occurred in ""alpha"" determinant region, the most frequent mutation position was aa 126 (I126S/N and T126A, 29.63%), and 145 (G145R/A, 25.93%), all of which were known to act as VEMs, accounting for more than half of the total mutation strains wither the ""alpha"" determinant."
Abstract: The hottest mutation position was aa126 (I126S/N and T126A, 29.63%), and aa 145 (G145R/A, 25.93%).
Result: Among 9 mutated isolates sharing 6 types of aa substitutions with HBV genotype B, three types of VEMs (T126A, Q129H and D144A) were also detected (Ta
Table: T126A
Molecular characterization of hepatitis B virus in Vietnam.
4Method: The S gene sequence was analyzed for mutations in the ""a"" determinant region (T116 N, P120S/T, I/T126S/A, Q129H/R, M133 L/T, K141E, P142S, D144E, and G145R), and other virulence associated mutations (N3S, V184A, and S204R)."
5Result: Among the isolates, 8.1% (11/135) had a mutation in the ""a"" determinant region including 2.2% (3/135) P120S/T, 2.2% (3/135)
Table: T126A
Characterization of hepatitis B virus in Amerindian children and mothers from Amazonas State, Colombia.
Discussion: Moreover, there are other reported escape mutants (P120T, T126A/S, and D144A/G) responsible for the evasion of vaccine-induced antibodies and therefore cause HBV infection in vaccinated individuals.
Higher detection rates of amino acid substitutions in HBV reverse transcriptase/surface protein overlapping sequence is correlated with lower serum HBV DNA and HBsAg levels in HBeAg-positive chronic hepatitis B patients with subgenotype B2.
PMID: 27006281
2016
Infection, genetics and evolution
Abstract: The most frequently detected substitutions were rtN134D/S (44/143, 30.8%) and sT126A/S (22/143, 15.4%), which were located in the RT A-B interdomain region and the corresponding antigenicity determinant region of S protein, respectively.
Characterization of Novel Hepatitis B Virus PreS/S-Gene Mutations in a Patient with Occult Hepatitis B Virus Infection.
Abstract: Among vaccinated individuals with breakthrough HBV infection, sG145R & sT126A/S mutations (which account for 48% of the mutants detected) have become prominent.
A novel nucleotide insertion in S gene of hepatitis B virus in a chronic carrier.
Abstract: S114T, C121Y, T126S/A, Q129K, G130R, T131N, M133T, G145R, N146D substitution and premature stop codon were also found in those clones.
Result: C121Y(TGC TAC), T126S/T126A(ACT TCT or ACT GCT), Q129K(CAA AAA), G130R(GGA AGA), G145R(GGA AGA) and other aa substitution compared with consensus sequence in MHR were also showed in figure 2.
HBV mutation literature information.
PMID: 
2017
Antiviral therapy
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