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 HBV mutation literature information.


  Subgenotypes and mutations in the s and polymerase genes of hepatitis B virus carriers in the West Bank, palestine.
 PMID: 25503289       2014       PloS one
Table: T125M


  Novel point and combo-mutations in the genome of hepatitis B virus-genotype D: characterization and impact on liver disease progression to hepatocellular carcinoma.
 PMID: 25333524       2014       PloS one
5Result: Interestingly, two mutations in ""a determinant region"" of surface T125M and T127L were noted inversely correlated with each other."
Result: T125M was found with high frequency (>52%) in nLF, LF and LC but low in HCC (32%) whereas T127L was noted only in LC (20%) and HCC (41%).
Table: T125M


  Molecular epidemiology and genotyping of hepatitis B virus of HBsAg-positive patients in Oman.
 PMID: 24835494       2014       PloS one
Table: T125M


  Molecular characterization of HBV strains circulating among the treatment-naive HIV/HBV co-infected patients of eastern India.
 PMID: 24587360       2014       PloS one
Abstract: Furthermore, the frequently occurring mutations in the major hydrophilic loop of the S gene include the T125M, A128V and M133I/L.
Discussion: Several amino acid substitutions within the major hydrophilic loop were observed in our study population which included Y100D, Q101R/H, M103V/I, T125M, A128V, M133L, D144E and G145S.


  Characterization of the occult hepatitis B virus variants circulating among the blood donors from eastern India.
 PMID: 24302857       2013       TheScientificWorldJournal
Discussion: Notably, T125M substitution was exclusive among the HBV/D3 isolates (data not shown).
Discussion: Similar association of this T125M substitution with HBV/D3 strains was documented in previous studies.


  Molecular evolutionary analysis and mutational pattern of full-length genomes of hepatitis B virus isolated from Belgian patients with different clinical manifestations.
 PMID: 20087936       2010       Journal of medical virology
Abstract: Within the immunological domain of the HBsAg gene, the most frequent substitutions were sT125M and sT118A.


  Expression of Hepatitis B virus surface antigen (HBsAg) from genotypes A, D and F and influence of amino acid variations related or not to genotypes on HBsAg detection.
 PMID: 20231988       2009       The Brazilian journal of infectious diseases
Abstract: However, the presence of two single variations, T143M in genotype A, and T125M in genotype D, produced a decrease of 44% and an increase of 34%, respectively, on HBsAg mean values in comparison with their consensus forms.
Abstract: However, unique amino acid substitutions not linked to genotypes, such as T125M and T143M described here, should have more implications in HBV immunological diagnostics than the set of variations characteristic of each HBV genotype.



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