Discussion: T115S, P120T, T125M, P127T, Q129R, K141R, and S143L were HBV mutants recorded among Egyptian blood donors with occult infection.
Natural variability in surface antigen and reverse transcriptase domain of hepatitis B virus in treatment-naive chronic HBV-infected Egyptian patients.
Abstract: Additionally, 11 occult samples (19 %) were detected, in which the predominant mutations of HBsAg were S143L (7 samples) followed by D144A and T125M (4 samples each).
Occult hepatitis B virus infection in HIV positive patients at a tertiary healthcare unit in eastern India.
Discussion: These HBV/D3 isolates exclusively carried the sT125M mutation in their surface gene and were different from the HBV/D3 isolates found among HBsAg positive patients.
HBV quasispecies composition in Lamivudine-failed chronic hepatitis B patients and its influence on virological response to Tenofovir-based rescue therapy.
Result: However, at the end of 24-week of TDF therapy, decline in the frequencies of rtM204I, rtL80I, rtN53D, rtY54H, rtH124N, rtN131D and rtH248N together with sS45A, sP46T, sI68T/A, sA/S113T,
Serological Patterns and Molecular Characterization of Occult Hepatitis B Virus Infection among Blood Donors.
Abstract: Mutations in the S region of HBV DNA included S114T, G119R, P120S, T125M, C139Y, T140I,
Result: Variants were found in 30.4% (21/69) of cases with OBI and included S114T, G119R, P120S, T125M, C139Y, T140I, C147W, T148A, A159V/G, E164D, V168A and R169C.
Genotyping and Mutation Pattern in the Overlapping MHR Region of HBV Isolates in Southern Khorasan, Eastern Iran.
Abstract: The most amino acid substitutions of surface protein were Q129H (34.42%) and A168V (8.2%), other escape mutants observed in this study were P127L/T, S117G, T125M, S143L, D144E and E164D.
Table: T125M
Discussion: The Q129H was the most frequently detected escape mutant in this study (34.42%), followed by P127L/T (3.27%) and E164D, S117G/T, D144E, T125M, S143L,
Molecular epidemiology of hepatitis B virus isolated from Bangladesh.
Result: Several mutations were observed in 'a' determinant region of S gene such as, T118V, T125M, T126I, P127T, A128V and T/S143L/M according to different genotypes of HBV (Table 1).
Table: Thr125Met
Discussion: Among which, Thr118Val, Thr125Met, Pro127Thr, Ala128Val and Thr/Ser143Leu/Met were observed in genotype D sequences, which is thought to have strong impacts on functions of S gene.
Characterization of hepatitis B virus surface antigen variability and impact on HBs antigen clearance under nucleos(t)ide analogue therapy.
Abstract: In our hands, a lower ELISA reactivity of HBV-vaccinated mice sera was observed against the sT125M mutant.
Abstract: The sT125M+sP127T combination was observed in four nonresolvers of six, corroborated by aa covariance analysis, associated with a lower predicted antigenicity than sT125T+sP127P.
Virological Characteristics of Acute Hepatitis B in Eastern India: Critical Differences with Chronic Infection.
Result: Important mutations in the MHL of the surface gene that were detectable in acute hepatitis, were T125M (2.5%), T126I (10%), and Y134F (35%).
Result: We noted significant changes at position 528 (C T) (amino acid substitution T125M) in the S gene and positions 1753 (T C), 1762(A T), 1764(G A), 1933 (T G), and 1938 (T C) in the BCP/PC region.
Hepatitis B surface gene variants isolated from blood donors with overt and occult HBV infection in north eastern Egypt.
Abstract: Amino acid escape mutation T125M was detected in only 2 samples of the occult infection group and in none of the overt group (P = 0.01).
Result: T125M was detected in one case in the anti-HBc+/anti-HBs + group (sample ID, OCU 18) and in one case in the anti-HBc+/anti-HBs- group (sample ID, OCU 158).
Result: The T125M HBsAg variant in the MHR was detected in one sample negative for anti-
Discussion: Significant predominance of amino acid substitutions T125M and Q129R was observed in HBsAg isolated from occult hepatitis B cases.
HBV mutation literature information.
PMID: 
2021
Infection and drug resistance
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