Analysis of entire hepatitis B virus genomes reveals reversion of mutations to wild type in natural infection, a 15 year follow-up study.
PMID: 34902556
2022
Infection, genetics and evolution
Abstract: Some sequences from subject CC246 had predicted escape substitutions (T123N, G145R) in the surface protein in 2004, 2013 and 2019 but none of the sequences from 2007 had these changes.
Analysis of the Physicochemical Properties, Replication and Pathophysiology of a Massively Glycosylated Hepatitis B Virus HBsAg Escape Mutant.
Introduction: Additional glycosylation sites on HBsAg other than the acceptor site at position N146, such as T123N or K160N, impaired or reduced the antibody recognition, respectively, while also reducing the virion formation.
Occult and active hepatitis B virus detection in donated blood in Sao Paulo, Brazil.
Abstract: Among them, T123N, G145A, and D144G high-impact immune escape mutations were identified.
A Hyper-Glycosylation of HBV Surface Antigen Correlates with HBsAg-Negativity at Immunosuppression-Driven HBV Reactivation in Vivo and Hinders HBsAg Recognition in Vitro.
Discussion: Furthermore, another study has shown that the N-linked glycosylation site T123N can strongly reduce virion assembly when introduced in a HBV genotype C backbone.
Discussion: In our study, T123N did not affect HBV replicative efficiency when present in a HBV genotype D backbone.
Discussion: Similarly, the detection of T123N is capable to affect HBsAg antigenic properties and has been observed in patients with atypical serological profiles for HBV infection.
Discussion: This is in agreement with a previous study by our group, showing the associated of T115N and T123N with occult HBV infection in the setting of HBV genotype D.
Molecular Epidemiology of Hepatitis B Virus in Turkish Cypriot.
PMID: 31880889
2019
Polish journal of microbiology
Table: T123N
[HBV pol/S gene mutations in chronic hepatitis B patients receiving nucleoside/nucleotide analogues treatment].
Discussion: Mutations T116N, T123N, G130N, and T131N + M133 T have been reported to reduce antigenicity and immunogenicity and rescue virion secretion in N146 mutants.
Discussion: The extremely low EIA reactivity observed for mutant TCT123-125NFT may be related to the combined effect of creation of an N-glycosylation site by T123N substitution and disruption of a putative disulfide bridge by the C124F substitution.
Evaluation of the pol/S Gene Overlapping Mutations in Chronic Hepatitis B Patients in Northern Cyprus.
PMID: 31880877
2019
Polish journal of microbiology
Result: Moreover, three patients in the non-HSCT group had predominant variants with sT116N, sT123N, and sG130N changes, which resulted in the addition of NLG sites by substitutions of threonine or glycine with asparagine.
HBV mutation literature information.
PMID: 
2022
PloS one
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