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 HBV mutation literature information.


  A multicentre molecular analysis of hepatitis B and blood-borne virus coinfections in Viet Nam.
 PMID: 22720022       2012       PloS one
Result: Mutations associated with immune escape were identified in 23.5% (n = 45/187) samples and included the following residues Y100C (n = 6), T118K (n = 1), P120L/Q/S/T (n = 10), T123A/N (n = 2), I126N/S (n = 8), P127S (n = 2), Q129R (n = 2), G130D/N/R (n = 1), T131I (n = 4), M133L/T (n = 18), G144E (n = 1) and G145A/R (n = 4).


  The detection of HBsAg mutants expressed in vitro using two different quantitative HBsAg assays.
 PMID: 22595307       2012       Journal of clinical virology
Abstract: However, HBsAg mutation T123A was under quantified by the Architect, whereas HBsAg mutations P142L, P142S and G145K yielded lower results in the Elecsys system.


  Prediction of conformational changes by single mutation in the hepatitis B virus surface antigen (HBsAg) identified in HBsAg-negative blood donors.
 PMID: 21087462       2010       Virology journal
Abstract: RESULTS: Three HBV variants (T123A, M133L and T143M) and a wild type sequence were analyzed together with frequently emerged variants T123N, M133I, M133T, M133V, and T143L.
Discussion: T123A mutant, on the other hand, involved changes from a polar Thr
Discussion: The degree of changes in antigenicity profile was highest in pattern T143M , followed closely by T123N and T143L, then lesser changes in M133I/T/V as well as T123A and M133L.


  Occult hepatitis B in blood donors in Indonesia: altered antigenicity of the hepatitis B virus surface protein.
 PMID: 21063484       2010       Hepatology international
Abstract: Seven of the viremic samples had nucleotide substitutions (A521G, A551T, C582T, and A562G) in the S gene, causing amino acid mutations (T123A, M133L, and T143M) in the 'a' determinant of HBsAg that resulted in changes in the predicted antigenicity.


  Detection of highly prevalent hepatitis B virus coinfection among HIV-seropositive persons in Ghana.
 PMID: 20631103       2010       Journal of clinical microbiology
Abstract: HBsAg mutations affected assay performance, including a T123A mutant that escaped detection by Architect.


  Comparison of the technical and clinical performance of the Elecsys HBsAg II assay with the Architect, AxSym, and Advia Centaur HBsAg screening assays.
 PMID: 20336717       2010       Journal of medical virology
Abstract: However, the Elecsys HBsAg II assay recognized a native mutant sample (L94S, L97V, L98V, T123A) that the Architect HBsAg assay failed to detect.


  Influence of HBV gene heterogeneity on the failure of immunization with HBV vaccines in eastern China.
 PMID: 19212700       2009       Archives of virology
Abstract: Interestingly, Thr123Ala and Gly145Arg were observed only in failure-group mothers, whereas Thr126Asn, Thr126Ser, Thr143Asn, Asp144Gly, and Asp144Ala were seen in the success group.


  Prevalence of naturally occurring surface gene variants of hepatitis B virus in nonimmunized surface antigen-negative Chinese carriers.
 PMID: 11679975       2001       Hepatology (Baltimore, Md.)
1Abstract: These changes involved 11 positions inside and 5 outside of the historical first and second loops of the ""a"" determinant, and included the following: Q101K, T115A, K122N, T123A, T126N, Q129N, G130R, T131I, M133T, F134L, C138Y, K141E, P142S, G145R, N146S, and C147F/R."



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