literature

HBV mutation literature information.

Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.

PMID: 35390033 2022 PloS one

Table: T123A/N

Molecular and serological characterization of occult hepatitis B among blood donors in Maputo, Mozambique.

PMID: 32997000 2020 Memorias do Instituto Oswaldo Cruz

Abstract: One escape mutation (T123A) associated with OBI and various amino acid substitutions for genotype A1 and E were observed.

Result: One escape mutation (T123A) associated with OBI in one sample was observed.

Table: T123A

Nearly half of Ultrio plus NAT non-discriminated reactive blood donors were identified as occult HBV infection in South China.

PMID: 31269905 2019 BMC infectious diseases

Result: P120Q (4.3%), T123A (4.3%), I126S, M133 T (8.7%), F134 L (4.3%) substitutions were found which might potentially affect HBsAg detection.

[HBV pol/S gene mutations in chronic hepatitis B patients receiving nucleoside/nucleotide analogues treatment].

PMID: 31130119 2019 Mikrobiyoloji bulteni

Abstract: Because of the HBV pol/S gene overlapping, in 27 patients immun-selected amino acid substitutions (sI110L, sT127P, sS114A, sT123A), in nine patients HBIg selected escape mutants (sP120R, sT123N, sE164D, sY134F, sQ129H, sT118A,

Molecular characterization of hepatitis B virus in blood donors in Botswana.

PMID: 30382563 2019 Virus genes

Result: Twelve mutations including diagnostic escape mutations (sY100C, sR122K, sT123A, sC124R, sM133T), vaccine escape mutations (sT126N, sQ129R, sM133L, sF134V) and immunoglobulin therapy failure (sG119R, sG130N,

PMID: 29859062 2018 BMC infectious diseases

Method: We determined the prevalence of 29 immune-associated escape mutations (sQ101K, sT114R, sP120S/T/A, sT123A/N, sT126N/S, sP127L, sA128V, sQ129R/N, sG130N/R, sT131I, sM133I/L/T,

Investigation of a Novel Hepatitis B Virus Surface Antigen (HBsAg) Escape Mutant Affecting Immunogenicity.

PMID: 28045894 2017 PloS one

Discussion: Antigenic index (Ai) values of four or more amino acids around amino acid position 123 were altered by a magnitude of -0.4 to +0.2 or more by the T123A or T123N mutations, respectively.

HBV genotypes and drug resistance mutations in antiretroviral treatment-naive and treatment-experienced HBV-HIV-coinfected patients.

PMID: 27167598 2017 Antiviral therapy

Method: The sequences were examined for known vaccine escape mutations (sG145R/A, sP142S, sI/T126A/N/I/S, sQ129H/R, sM133L, sD144A/E, sP120S/E, sK141E, sP134I, and sT116N), immunoprophylaxis escape mutations (

Discordant diagnostic results due to a hepatitis B virus T123A HBsAg mutant.

PMID: 27133305 2016 Diagnostic microbiology and infectious disease

Abstract: Such discordance has been observed repeatedly in Canada with samples having a mutation at HBsAg codon 123 (sT123A).

Abstract: The sT123A mutation leads to loss of detection by immunoassays commonly used in Canadian diagnostic laboratories, which may produce misleading results and diagnoses.

Ultradeep Sequencing for Detection of Quasispecies Variants in the Major Hydrophilic Region of Hepatitis B Virus in Indonesian Patients.

PMID: 26202119 2015 Journal of clinical microbiology

Abstract: The most frequent MHR variants related to immune evasion in the major and intermediate populations were P120Q/T, T123A, P127T, Q129H/R, M133L/T, and G145R.

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