literature

HBV mutation literature information.

Global prevalence and phylogeny of hepatitis B virus (HBV) drug and vaccine resistance mutations.

PMID: 33893696 2021 Journal of viral hepatitis

Result: T118A/R/V, A128V and S/T143L/M had the highest prevalence in genotype D and in Europe, being present >3% of the sequences.

Result: Other VEMs that had an overall prevalence of >1% were T118A/R/V, M133I/L/T, A128V, Q129H/N/R, G145A/R, P120S/T and S/T143L/M (Figure 2A).

Figure: T118X represents T118A/R/V; M133X represents M133I/L/T; Q129X

Investigation of immune escape-associated mutations of hepatitis B virus in patients harboring hepatitis B virus drug-resistance mutations.

PMID: 32994690 2020 World journal of gastroenterology

Abstract: In particular, these mutations were sQ101H/K/R, sS114A/L/T, sT118A/K/M/R/S/V, sP120A/L/Q/S/T, sT/I126A/N/P/S, sM133I/L/T, sC137W/Y, sG145A/R, and sA159G/V.

Result: In particular, mutations were detected in 67/63

Nearly half of Ultrio plus NAT non-discriminated reactive blood donors were identified as occult HBV infection in South China.

PMID: 31269905 2019 BMC infectious diseases

Abstract: Most OBI strains were wild-type HBV, but some substitutions V168A, S174 N, V177A, Q129R/L/H, G145A/R in S region of genotype B (OBIB) and T47K/V/A, P49H/L, Q101R/H/K, S174 N, L175S, V177A, T118 M/R/K, G145R/A/K/E, R160K/N in S region of genotype C (OBIC) strains were identified in high frequency.

Hepatitis B infection among HIV infected individuals in Gabon: Occult hepatitis B enhances HBV DNA prevalence.

PMID: 29315352 2018 PloS one

Method: In addition, we looked for Vaccine Escape Mutants (VEMs) and polymorphic mutations outside (Y100C, Q101H, S117N, T118R and P120S) and within the HBsAg immuno-dominant 'a' determinant (I/T126A/N, A128V, Q129H/R, G130N, M133L/T, K141E, S143L, D144A/H/E and G145R).

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