literature

HBV mutation literature information.

Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.

PMID: 35390033 2022 PloS one

Table: T118M

Investigation of immune escape-associated mutations of hepatitis B virus in patients harboring hepatitis B virus drug-resistance mutations.

PMID: 32994690 2020 World journal of gastroenterology

Result: In particular, mutations were detected in 67/63/168 of 298 sQ101H/K/R-positive patients, 39/2/76 of 117 sS114A/L/T-positive patients, 5/5/15/3/1/2 of 31 sT118A/K/M/R/S/V-positive patients, 3/0/0/23/81 of 107 sP120A/L/Q/S/T-positive patients, 94/58/0/214 of 366 sT/I126A/N/P/S-positive patients, 14/46/136 of 196 sM133I/L/T-positive patients, 1/8 of 9 sC137W/Y-positive patient

Nearly half of Ultrio plus NAT non-discriminated reactive blood donors were identified as occult HBV infection in South China.

PMID: 31269905 2019 BMC infectious diseases

Abstract: Most OBI strains were wild-type HBV, but some substitutions V168A, S174 N, V177A, Q129R/L/H, G145A/R in S region of genotype B (OBIB) and T47K/V/A, P49H/L, Q101R/H/K, S174 N, L175S, V177A, T118 M/R/K, G145R/A/K/E, R160K/N in S region of genotype C (OBIC) strains were identified in high frequency.

Nucleotide Substitutions in Hepatitis B Viruses Derived from Chronic HBV Patients.

PMID: 31308922 2019 Mediterranean journal of hematology and infectious diseases

Result: Five (5) mutations were detected within the surface gene in the patients (F8L, T118M, E164D, T189I, and W196L).

Result: The frequency of mutations in the MHR was seen in 18.0% (6/33) of isolates (T118M, E164D).

Analysis of HBV basal core promoter/precore gene variability in patients with HBV drug resistance and HIV co-infection in Northwest Ethiopia.

PMID: 29408943 2018 PloS one

Table: T118M

The Thr to Met substitution of amino acid 118 in hepatitis B virus surface antigen escapes from immune-assay-based screening of blood donors.

PMID: 26873737 2016 The Journal of general virology

Abstract: A mutagenesis assay indicated that the Thr to Met substitution at aa 118 was the determinant for escape from HBsAg ELISA detection.

Decreased antigenicity profiles of immune-escaped and drug-resistant hepatitis B surface antigen (HBsAg) double mutants.

PMID: 24053482 2013 Virology journal

Result: Similarly, the differences in avidity (as determined by the slope of the curve) was indistinguishable between the sT118M mutant and sT118M-rtM204V (sT118M- sW196S) mutant for all five assays, suggesting that drug-resistant YMDD mutants caused a negligible loss in antigenicity for immune-escaped sT118M HBsAg (Figure 2).

Discussion: The immune escape mutant sT118M HBsAg can decrease the

Hepatitis B surface antigen variants in voluntary blood donors in Nanjing, China.

PMID: 22500577 2012 Virology journal

Result: D99N, Y100F, Q101R/H, L110I, T113S, S114T, S117T, T118M, I126T/V, W165L, and V168A, which may be associated with antigenicity of HBsAg.

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