literature

HBV mutation literature information.

Occult HBV Infection May Be Transmitted through Close Contact and Manifest as an Overt Infection.

PMID: 26457811 2015 PloS one

Result: T118K and T123N may result in failure to detect of HBsAg.

Result: Seven clones have the same amino acid substitution pattern as that in the son: T118K, T123N

Result: The T118K and N145A substitutions may result in vaccine escape.

Hepatitis B surface antigen genetic elements critical for immune escape correlate with hepatitis B virus reactivation upon immunosuppression.

PMID: 25418031 2015 Hepatology (Baltimore, Md.)

Abstract: Of the 13 HBsAg mutations found in these patients, 8 of 13 (M103I-L109I-T118K-P120A-Y134H-S143L-D144E-S171F) reside in a major hydrophilic loop (target of neutralizing antibodies [Abs]); some of them are already known to hamper HBsAg recognition by humoral response.

Molecular epidemiology and genotyping of hepatitis B virus of HBsAg-positive patients in Oman.

PMID: 24835494 2014 PloS one

Table: T118K/A

A multicentre molecular analysis of hepatitis B and blood-borne virus coinfections in Viet Nam.

PMID: 22720022 2012 PloS one

Result: Mutations associated with immune escape were identified in 23.5% (n = 45/187) samples and included the following residues Y100C (n = 6), T118K (n = 1), P120L/Q/S/T (n = 10), T123A/N (n = 2), I126N/S (n = 8), P127S (n = 2), Q129R (n = 2), G130D/N/R (n = 1), T131I (n = 4), M133L/T (n = 18), G144E (n = 1) and G145A/R (n = 4).

Late hepatitis B virus reactivation after lamivudine prophylaxis interruption in an anti-HBs-positive and anti-HBc-negative patient treated with rituximab-containing therapy.

PMID: 22138369 2012 The Journal of infection

Abstract: The patient carried a hepatitis B genotype D virus harbouring a single immune escape mutation, sT118K.

[Characterisation of an HBsAg mutant of hepatitis B virus (HBV) isolated from a dialysed patient involved in an occupational accident].

PMID: 16273841 2005 La Medicina del lavoro

Abstract: RESULTS AND CONCLUSIONS: A threonine to lysine substitution at position 118 of HBsAg (Thrll8Lys) was observed in the analysed viral aminoacid sequence.

"Characterization of a novel hepatitis B virus mutant: demonstration of mutation-induced hepatitis B virus surface antigen group specific ""a"" determinant conformation change and its application in diagnostic assays."

PMID: 11696228 2001 Transfusion medicine (Oxford, England)

1Abstract: Interestingly, none of the mutations was found within the group-specific ""a"" determinant region (124-147) and, specifically, two of the five mutations, T118K and P120Q, were located only a few amino acids adjacent to the 124-147 region."

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