literature

HBV mutation literature information.

Occult hepatitis B virus infection in anti-HBs-positive infants born to HBsAg-positive mothers in China.

PMID: 23951004 2013 PloS one

Discussion: identified the OBI-associated mutations Y100S, T116N, R122P, S143L and S167L from a large-sample, blood-donor study.

Novel HBsAg markers tightly correlate with occult HBV infection and strongly affect HBsAg detection.

PMID: 22086128 2012 Antiviral research

Abstract: By co-variation analysis, correlations were observed for R122P+S167L (phi=0.68, P=0.01), T116N+S143L (phi=0.53, P=0.03), and Y100S+S143L (phi=0.67, p<0.001).

Abstract: Mutants (obtained by site-directed mutagenesis) carrying T116N, T116N+S143L, R122P, R122P+Q101R, or R122P+S167L strongly decreased HBsAg-reactivity (54.9+-22.6S/CO, 31.2+-12.0S/CO, 6.1+-2.4S/CO, 3.0+-1.0S/CO and 3.9+-1.3S/CO, respectively) compared to wild-type (306.8+-64.1S/CO).

Emergence of an S gene mutant during thymosin alpha1 therapy in a patient with chronic hepatitis B.

PMID: 9728561 1998 The Journal of infectious diseases

Abstract: Sequence analysis revealed an S gene mutant in HBsAg-seronegative serum with two consecutive amino acid substitutions: threonine115-to-isoleucine and threonine116-to-asparagine, whereas no amino acid substitution or deletion was found in the pre-S region.

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