Introduction: These mutations include A2159G, A2189C and G2203W at C gene, Introduction: While A1762T/G1764A, C1653T, A799G, A987G, T1055A, pre-S deletion could be detected in the plasma long before PLC diagnosis, T1753C, C1766T and T1768A mutations appeared only one or two years before PLC diagnosis.,,These observations provide valuable information for HCC prediction and screening when using HBV mutations as the marker.
Mutations in hepatitis B virus polymerase are associated with the postoperative survival of hepatocellular carcinoma patients.
Abstract: RESULTS: There were 15 candidate mutations identified from the discovery set, with A799G and T1055A being consistently associated with HCC across all studies.
Discussion: Unlike the mutations A799G and T1055A, A987G does
Discussion: We found that the mutations A799G, A987G, and T1055A were detectable in >75% patients (3 of 4 patients for A799G, 2 of 2 patients for A987G, and 4 of 5 patients for T1055A) 4-5 years before the clinical diagnosis of HCC (Table S3 in File S1).
Novel point and combo-mutations in the genome of hepatitis B virus-genotype D: characterization and impact on liver disease progression to hepatocellular carcinoma.
Discussion: These mutations might not affect HBsAg but could alter polymerase activity as another mutation in this region, T1055A has been reported to affect the conformation of two helices and impair HBV DNA-primer interaction.
HBV mutation literature information.
PMID: 
2018
Hepatoma research
Browser Board
Co-occurred Entities
Filtrator
ViMRT