HBV mutation literature information.


  Novel point and combo-mutations in the genome of hepatitis B virus-genotype D: characterization and impact on liver disease progression to hepatocellular carcinoma.
 PMID: 25333524       2014       PloS one
Result: T1050G/A and A1053G were noticed first time in HBV-genotype D.
Result: Although the prevalence of A1053G was extremely high in both LC (50%) and HCC (50%), it was only 6% in nLF and 11% in LF (p = 0.081) whereas, T1050G/A and their combination T1050G/A+A1053G showed significant escalating trend over the course of infection from nLF (18%, 0%) to HCC (54%, 32%) through LF (22%, 11%) and LC (35%, 25%) (p = 0.035, 0.008 respectively).
Table: T1050G/A



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