In silico functional and structural characterization of hepatitis B virus PreS/S-gene in Iranian patients infected with chronic hepatitis B virus genotype D.
Discussion: (2013) have similarly detected such mutations (S45 T/A, N131T, I194V, and S207N) in the S region and recommended further research in this domain.
HBV quasispecies composition in Lamivudine-failed chronic hepatitis B patients and its influence on virological response to Tenofovir-based rescue therapy.
Result: After implementing Benjamini-Hochberg correction, 3 (rtM204I, rtL80I, rtY54H) out these 7 RT substitutions and 6 (sS45A, sP46T, sI68T/A, sT118V, sW196L and sR210N) out of 8 S-substitutions remained significantly less frequent in the responders (Table 4).
Result: Among these, only one
Naturally occurring hepatitis B virus B-cell and T-cell epitope mutants in hepatitis B vaccinated children.
Abstract: Several immune-epitope mutants, such as S45T/A, N131T, I194V, and S207N in S, were detected in all isolates.
Conclusion: Several immune-epitope mutants, such as S45T/A, N131T, I194V, and S207N in S, were detected in all isolates and needed to explore their role in HBV infection.
Result: Four replacements (S45T/A, N131T, I194V, and S207N) within the immune epitopes were observed in all isolates.
Unusual naturally occurring humoral and cellular mutated epitopes of hepatitis B virus in a chronically infected argentine patient with anti-HBs antibodies.
PMID: 16757620
2006
Journal of clinical microbiology
Abstract: Observed replacements included both humoral and/or cellular (major histocompatibility complex class I [MHC-I] and MHC-II) HBV mutated epitopes, such as S45A, P46H, L49H, C107R, T125A, M133K, I152F, P153T, T161S, G185E, A194T, G202R, and I213L.
HBV mutation literature information.
PMID: 
2022
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