literature

HBV mutation literature information.

rt269I Type of Hepatitis B Virus (HBV) Polymerase versus rt269L Is More Prone to Mutations within HBV Genome in Chronic Patients Infected with Genotype C2: Evidence from Analysis of Full HBV Genotype C2 Genome.

PMID: 33803998 2021 Microorganisms

Result: We found a total of seven types of signature NS mutations in the Pol region (three types in RT, one type in the terminal protein (TP) region, two types in the spacer region and one type in the RNaseH region), of which all seven (rtN139K/H, rtM204I/V and rtI224V in RT, D16A/E/N/V in TP, S314P and F321L in Spacer and D828A/V in the RNaseH region) were rt269I signature types.

Table: S314P

Mutations in hepatitis B virus polymerase are associated with the postoperative survival of hepatocellular carcinoma patients.

PMID: 29287068 2017 PloS one

Abstract: The mutations at the 31 (Ser314Pro), 529 (Asp480Asn), and 1078 (Ser663Ala) sites all resulted in amino acid changes in hepatitis B virus polymerase and were associated with shortened life-span.

Result: As shown in Table 4, after adjusting for clinical characteristics, the following three mutation sites were identified as independent predictors of a shorter survival period in HCC at statistically significant levels: mutation at nucleotide 31 (RR, 8.929; 95% CI, 3.433-23.22; P = 0.000) inducing the 314 Ser to Pro amino acid substitution in the spacer domain; at nucleotide 529 (RR, 5.656; 95% CI, 1.599-19.999; P = 0.007) inducing the 480 Asp to Asn amino acid substitution; and at nucleotide 1078 (RR, 3.442; 95% CI, 1.070

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