Molecular characterization of hepatitis B virus (HBV) isolated from a pediatric case of acute lymphoid leukemia, with a delayed response to antiviral treatment: a case report.
Abstract: In addition to the LAM mutations (rtS256G and rtM267L), missense mutations in B-cell, T-cell, HLA class I and II-restricted epitopes emerged, which were to evade and escape host surveillance, leading to delayed viral clearance, persistence and disease progression.
Table: S256G
Discussion: In fact, in addition to the immune escape mutations, two lesser-known LAM resistance mutations (rtS256G and rtM267L) developed (Table 1), which were previously identified in LAM-failed CHB patients.
High Prevalence of Preexisting HBV Polymerase Mutations in Pregnant Women Does Not Limit the Antiviral Therapy Efficacy.
PMID: 33986897
2021
The Canadian journal of infectious diseases & medical microbiology
Result: However, rtI169 T, rtA194 T, rtV173 L, rtL180 M, rtL82 M, rtS85 A, rtV207I, rtL217 R, and rtS/C256G mutations were not present before TBV treatment.
COLD-PCR Method for Early Detection of Antiviral Drug-Resistance Mutations in Treatment-Naive Children with Chronic Hepatitis B.
Discussion: In our data, the LMV-associated rtV207M was the most abundant (38.0%), followed by ADF-associated rtN238T (9.9%), ADF-associated rtN238A (5.6%), LMV-associated rtV207L (1.4%), LMV-associated rtS213T (1.4%), LMV-associated rtS256G (1.4%), LMV-associated rtL229V (0.7%), ADF-associated rtN238K (0.7%), and ADF-associated rtP237T (0.7%).
Mutational characterization of HBV reverse transcriptase gene and the genotype-phenotype correlation of antiviral resistance among Chinese chronic hepatitis B patients.
Result: Putative resistance mutations were observed at 8 AA sites among the panel of treatment-naive patients; they were rtV191I, rtS213T, rtV214A, rtE218D, rtL229V, rtI233V, rtN238S, rtS/C256G.
Viral quasispecies of hepatitis B virus in patients with YMDD mutation and lamivudine resistance may not predict the efficacy of lamivudine/adefovir rescue therapy.
PMID: 30906435
2019
Experimental and therapeutic medicine
Result: Common and frequent mutations identified in the cohort of the present study included rtL80V/I, rtV84M, rtL91I, rtN118H/D/T, rtT128A, rtL180M, rtT184L/S/A, rtV191I, rtS202G, rtV207I/M, rtS213T
Characterization and Clinical Significance of Natural Variability in Hepatitis B Virus Reverse Transcriptase in Treatment-Naive Chinese Patients by Sanger Sequencing and Next-Generation Sequencing.
PMID: 31189581
2019
Journal of clinical microbiology
Result: Also, rtS213T, rtV214A, rtL229G/V/W/F, N/H238D/T, and S/C256G were detected in 13 patients by both Sanger sequencing and NGS, including 3 patients with rtS213T (98.44%, 46.88%, and 80.97% by NGS), 2 with rtV214A (49.18% and 99.24%), 1 with rtL229V (50.84%), 1 with rtN238T (98.85%), 5 with S/C256G (97.28%, 97.93%, 92.26%, 97.79%, and 98.31%), and 1 w
Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression.
PMID: 29713126
2018
World journal of gastroenterology
Method: A total of 26 types of RT mutations, including rtS53N, rtT54N, rtL82M, rtV84M, rtS85A, rtI91L, rtY126C, rtT128I/N, rtN139D, rtW153Q, rtF166L, rt
Clinical features and viral quasispecies characteristics associated with infection by the hepatitis B virus G145R immune escape mutant.
Result: The frequencies of four mutations in the S region (G145R, K160R, L173P and Q181R), four mutations in the RT region (R153Q, S256G, C332S and L336M) and five mutations in the X region (S54P, L55F, R56P, L58P and C69P) decreased in the 8th week, whereas the frequencies of many mutations in the S, P and X regions clearly increased.
Di
Dynamics of Genotypic Mutations of the Hepatitis B Virus Associated With Long-Term Entecavir Treatment Determined With Ultradeep Pyrosequencing: A Retrospective Observational Study.
Result: Resistance mutations displayed low levels of fluctuation (<7%), and other nonresistant variants (rtN248H/
Figure: Additionally, rtS256G substitutions were maintained at a high level (>55%).ETV = entecavir, DNA = di-ribonucleic acid, HBV = hepatitis B virus, RT = reverse transcriptase.
Figure: Two variants (rtI187L/rtV191I) rose to a high level during the 4th year (84.43% /83.41%), and 2 other variants, namely, rtN248H and rtS256G, were maintained at a high level (>60%).
Characterization of hepatitis virus B isolated from a multi-drug refractory patient.
HBV mutation literature information.
PMID: 
2022
BMC pediatrics
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