Detection of circulating hepatitis B virus immune escape and polymerase mutants among HBV-positive patients attending Institut Pasteur de Bangui, Central African Republic.
PMID: 31682960
2020
International journal of infectious diseases
Discussion: In addition to the three IEMs identified, several surface protein mutations were identified (sP56Q, sT57I, sN59S, sP62L, sI110L, sS140T, sE164G, sS207N, and sL216*), which have also been reported in previous studies (Mello et al.,; Lin et al.,; Munshi et al.,; Qin and Liao,).
In silico functional and structural characterization of hepatitis B virus PreS/S-gene in Iranian patients infected with chronic hepatitis B virus genotype D.
Conclusion: This research attempted to investigate several new substitution sites (T126N, N131T, P142L, and S207N) identified in two HBV S proteins.
Discussion: (2013) have similarly detected such mutations (S45 T/A, N131T, I194V, and S207N) in the S region and recommended further research in this domain.
Discussion: In fact, concerning our sequences, several immune epitope mutations including S45T, T113S, N131T, I194V and P142L in MK355500 and PMID: 30943997
2019
Virology journal
Result: S (aa 1-226) substitutions were: D144DN, M198I, S207 N, V209 L.
Mutation profiling of the hepatitis B virus strains circulating in North Indian population.
Discussion: Table 1 shows that the mutations found upstream-I86F, I92T, and I110L-and those found downstream-T189I, Y200F, S204R, Y206L, S207N, S210R, L213I, and L213F-were recorded in different studies but were not associated with critical functions (Table 1).
Naturally occurring hepatitis B virus B-cell and T-cell epitope mutants in hepatitis B vaccinated children.
Abstract: Several immune-epitope mutants, such as S45T/A, N131T, I194V, and S207N in S, were detected in all isolates.
Conclusion: Several immune-epitope mutants, such as S45T/A, N131T, I194V, and S207N in S, were detected in all isolates and needed to explore their role in HBV infection.
Result: Four replacements (S45T/A, N131T, I194V, and S207N) within the immune epitopes were observed in all isolates.
[Heterogeneity of hepatitis B virus and diagnostic potential of modern test systems for the detection of HBsAg].
PMID: 22442974
2012
Zhurnal mikrobiologii, epidemiologii i immunobiologii
Abstract: Amino acid substitutions G145A, M133I, S132T localized in the main hydrophilic region and P217L, S207N, V184A localized in the C-end of the protein C that are connected with diagnostic and vaccine escape were identified in 5 isolates.
Surface gene mutations of hepatitis B virus among high-risk patients with occult hepatitis B virus infection.
PMID: 19903586
2010
Diagnostic microbiology and infectious disease
Abstract: Amino acid substitution at amino acid position 207(S207N) was found in the other isolates.
The profile of mutational clusters associated with lamivudine resistance can be constrained by HBV genotypes.
Abstract: Both sF220L and sS207N co-localized in the fourth transmembrane HBsAg domain.
Abstract: Covariate analysis showed that rtM204V clusters with rtL180M, rtL229V (corresponding to sF220L in the HBsAg), and, interestingly, with HBsAg mutation sS207N (bootstrap=0.95).
HBV mutation literature information.
PMID: 
2022
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