Introduction: They include rtI169T, rtL180M, rtS184S/A/I/L/G/C/M, M204I/V, rtS202G/I, and rtM250I/V.
YMDD Motif Mutation Profile Among Patients Receiving Liver Transplant Due to Hepatitis B Virus Infection With Long Term Lamivudine/Immunoglobulin Therapy.
Abstract: Critical M204I mutation, as a proof for resistance to LAM, was detected among 46% of the subjects and natural entecavir resistance (S202I) was also distinguished in one subject.
Result: As a rare case, natural mutation of S202I, responsible for resistance to ENC, occurred before starting drug consumption (in patient SH1).
Table: S202I
Figure: A S202I mutation was also detected in one subjects (SH1), indicating the natural entecavir resistance.
Discussion: The sequential analyses of the current study genes also revealed the natural presence of ENC resistance mutation (S202I), not previously reported in Iran.
Novel natural mutations in the hepatitis B virus reverse transcriptase domain associated with hepatocellular carcinoma.
Result: It is worth noting that we did not observe any of the common NA-related resistance mutations including rtM204V/I, rtS202C/G/I, rtL180M, rtA181T/V, rtT184A/I/L/G/C/M, rtA194T, rtI169T, rtV173L, rtL80I, rtN236T, and PMID: 24637457
2014
PloS one
Table: S202I
Discussion: Entecavir associated drug resistant mutations I169N, A181G, S202I reported earlier were observed in 4 cases.
Drug-resistance associated mutations in polymerase (p) gene of hepatitis B virus isolated from malaysian HBV carriers.
Abstract: A number of significant drug resistant mutations were found in five patients including S202I, N236T, M250L, L180M/V, M204I, A181T, T184G, M250V, and V173L.
Result: Patient 830757 also had multiple mutations in HBV P gene, which were S202I, N236T, and M250L.
Table: S202I
Establishment of drug-resistant HBV small-animal models by hydrodynamic injection.
Introduction: Interestingly, resistance to ETV includes LAM resistance mutations, rtM250V+-rtI169T+rtM204V+rtL180M and rtT184G+rtS202I+rtM204V+rtL180M.
Discussion: The importance of pre-existing ETV resistant HBV variants was highlighted in a previous study, in which three out of 111 (2.7%) patients had substitutions in the HBV polymerase gene corresponding to variants associated with ETV resista
Drug-related mutational patterns in hepatitis B virus (HBV) reverse transcriptase proteins from Iranian treatment-naive chronic HBV patients.
Result: rtV173L, rtL180M, rtA181V/T, rtT184G, rtS202I, rtM204V/I, rtN236T and rtM250V were first studied and then, others residues with changes present in at least two patients were further considered.
HBV mutation literature information.
PMID: 
2015
PloS one
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