Discussion: S174N (S) for instance had been observed in our study with the highest OR and relative high PPV, NPV and specificity (75%, 81.1% and 99.5%, respectively) but its sensitivity was only 6.1% (S3 Table).
Discussion: Outside of the MHR region we also detected higher rates of other 3 S mutations T47A/E/V/K, Discussion: The final findings had recognized 5 mutations (W4P/R/Y on the PreS1 region and T47A/E/V/K, P120S/T, S174N, P203R on the S region) that significantly related to HCC.
Molecular characteristics of HBV infection among blood donors tested HBsAg reactive in a single ELISA test in southern China.
Abstract: Five of the ten mutations (E2G, D144E, G145R, V168A and S174N) strongly decreased extracellular HBsAg level (P < .05) in the transfection system.
Abstract: Ten occult infection-related mutations (E2G, Q101R, K122R, M133T, D144E, G145R, V168A, S174N, L175S and I226S) were significantly more frequent in the occult infection group (P < .05).
Molecular and serological characterization of occult hepatitis B among blood donors in Maputo, Mozambique.
PMID: 32997000
2020
Memorias do Instituto Oswaldo Cruz
Table: S174N
Effect of hepatitis B virus (HBV) surface-gene variability on markers of replication during treated human immunodeficiency virus-HBV infection in Western Africa.
Abstract: Most OBI strains were wild-type HBV, but some substitutions V168A, S174 N, V177A, Q129R/L/H, G145A/R in S region of genotype B (OBIB) and T47K/V/A, P49H/L, Q101R/H/K, S174 N, L175S, V177A, T118 M/R/K, G145R/A/K/E, R160K/N in S region of genotype C (OBIC) strains were identified in high frequency.
D
A new vaccine escape mutant of hepatitis B virus causes occult infection.
PMID: 25692622
2015
Human vaccines & immunotherapeutics
Abstract: Three new mutations (S171F, S174N and Q181R) at the antigenic epitopes of HBV presented by HLA class I molecules are found.
Genotyping and virological characteristics of hepatitis B virus in HIV-infected individuals in Sudan.
PMID: 25449246
2014
International journal of infectious diseases
Abstract: The following mutations in the S region could account for the HBsAg negativity: sM133T, sE164G, sV168G, and sS174N.
Genotyping and molecular characterization of hepatitis B virus from human immunodeficiency virus-infected individuals in southern Africa.
Result: When comparing the frequency of mutations in HBsAg+ve and HBsAg-ve individuals, only sS174N occurred more frequently in HBsAg-ve individuals (p<0.05).
Discussion: Although, with the exception of sS174N, there was no significant difference between the frequency of the mutations in the S region from HBsAg+ve and HBsAg-ve participants, there were a number of mutations that could account for the inability to detect HBsAg.
Discussion: The reactivation markers V168A occurred together with S174N, which was only found in isolates from <
HBV mutation literature information.
PMID: 
2022
PloS one
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