Abstract: The kit specifically recognized the S143L substitution in contrast to the S143T variant.
Recombinant HBsAg of the Wild-Type and the G145R Escape Mutant, included in the New Multivalent Vaccine against Hepatitis B Virus, Dramatically Differ in their Effects on Leukocytes from Healthy Donors In Vitro.
Abstract: CONCLUSION: ELISA-based detection of escape mutations S143L, D144E and G145R can be used for routine diagnostics, especially in the risk groups.
Recombinant HBsAg of the Wild-Type and the G145R Escape Mutant, included in the New Multivalent Vaccine against Hepatitis B Virus, Dramatically Differ in their Effects on Leukocytes from Healthy Donors In Vitro.
Introduction: Electron microscopy revealed unusual oval-shaped 60-70 nm HBV structures in serum and 100-200 nm structures in a preparation of the purified G145R mutant, which were not seen in samples of wild-type HBV or an S143L escape mutant.
Introduction: In addition, studies of sera from vaccinated people have shown that the widely used vaccines provide virtually no cross-reactive protection against the G145R mutant in the virus neutralization assay, in contrast to, for example, another immune-escape mutant S143L.
Global prevalence and phylogeny of hepatitis B virus (HBV) drug and vaccine resistance mutations.
Method: We also considered eight VEMs (C139S, S/T140I, P142S, S/T143L/M, D144A/E/G/N, G145A/E/R, K141A/I/R and C147S) which are located within the epitope region neutralized by the HBV vaccine (aa139-147).
Result: We considered the distribution of 12 RAMs (S106C/G, D134E, R153W/Q, V173L, L180M, A181T/V, A194T, A200V, PMID: 33836203
2021
Virus research
Abstract: Additionally, 11 occult samples (19 %) were detected, in which the predominant mutations of HBsAg were S143L (7 samples) followed by D144A and T125M (4 samples each).
Characterization of Antigen Escape Mutations in Chronic HBV-Infected Patients in Upper Egypt.
Discussion: T115S, P120T, T125M, P127T, Q129R, K141R, and S143L were HBV mutants recorded among Egyptian blood donors with occult infection.
Discussion: S143L, G145R/A, and D144E/A were the highest reported mutations among our cohort, which were detected in 25%, 20%, and 15% of the patients, respectively.
Discussion: Ma and Wang reported that eight mutations (
Discussion: Similar to our findings, Zeid et al reported that S143L mutation is the predominant mutation (6.8%) among Egyptian CHB patients.
Molecular Epidemiology of Hepatitis B Virus in Turkish Cypriot.
PMID: 31880889
2019
Polish journal of microbiology
Table: S143L
Patterns of hepatitis B virus S gene escape mutants and reverse transcriptase mutations among genotype D isolates in Jordan.
Introduction: Among other commonly detected vaccine-escape mutants are: P120Q, Q129H, F134Y/L, S143L and D144A/E.
Discussion: In Turkey, the most frequent mutations observed were T143M and K122R, whereas in Egypt 14.8% presented with mutations in the MHR, and eight different mutations were discovered: R122K, S143L, L109P, S114P, S117N, P127S, P127T and Y134F.
High rates of chronic HBV genotype E infection in a group of migrants in Italy from West Africa: Virological characteristics associated with poor immune clearance.
Abstract: RT sequence analysis showed the presence of a number of immune escape mutations: strains from all of the patients had a serine at HBsAg position 140; 3 also had T116N, Y100C, and P142L+S143L substitutions; and 1 had a G112R substitution.
Result: Additional immune escape mutations were detected in 3 patients: T116N, Y100C, and P142L+S143L (Fig 1).
Hepatitis B infection among HIV infected individuals in Gabon: Occult hepatitis B enhances HBV DNA prevalence.
Method: In addition, we looked for Vaccine Escape Mutants (VEMs) and polymorphic mutations outside (Y100C, Q101H, S117N, T118R and P120S) and within the HBsAg immuno-dominant 'a' determinant (I/T126A/N, A128V, Q129H/R, G130N, M133L/T, K141E, S143L, D144A/H/E and G145R).
HBV mutation literature information.
PMID: 
2022
Voprosy virusologii
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