Abstract: Mutations at HBsAg amino acid positions 143-145 are the most common (46%) with the mutation serine 143 to leucine the most frequently occurring change (28%).
Result: A total of 22 strains had mutations only within E2; S143L (n = 11), S143SL (n = 3), D144A (n = 1), D144E (n = 2), D144DG (n = 1), G145A (n = 2), and G145GR (n = 2).
Result: There were 2 strains that had mutations in both E1 and E2; T123TS plus S143L and T123TI plus S143SL.
Characteristics of escape mutations from occult hepatitis B virus infected patients with hematological malignancies in South Egypt.
Result: Of the 12 samples, escape mutation Q129R was present in 7, while P120T was detected in 4 and S143L was present in 1, suggesting that the clones with 129R mutation were from a minor population with relatively low HBV-DNA levels.
Table: S143L
Figure: Expression of hepatitis B virus DNA and antigens after transfection of Huh 7 cells with wild type hepatitis B virus genotype D clone (WT) and mutants with S<
Discussion: We detected two previously reported escape mutations P120T and S143L that were associated with occult HBV infection, and investigated the mechanism by which these mutations cause occult infection using an in vitro system.
Investigation of a Novel Hepatitis B Virus Surface Antigen (HBsAg) Escape Mutant Affecting Immunogenicity.
Discussion: found no reactivity of HBsAg using two commercial diagnostic assays whose sequences had simultaneous mutations at various positions, including an amino acid at 100 (Y100S), and this may have been due to mutations at other sites (T118V/R122K/M133I/Y134N/P142S/S143L/G145K).
Prevalence of mutations within major hydrophilic region of hepatitis B virus and their correlation with genotypes among chronically infected patients in Egypt.
PMID: 27055927
2016
Arab journal of gastroenterology
Abstract: The second loop contained six patients, all with one mutation, S143L, which was most frequently encountered in this study (6.8%).
[Atypical serological profiles in hepatitis B infections: investigation of S gene mutations in cases with concurrently positive for HBsAg and anti-HBs].
Abstract: Sequence analysis of seven samples showed S gene mutations in two samples, one was sS143L with sS193L, a HBV vaccine escape mutation, and the other was sP120R, a HBV immune escape mutation.
Genotyping and Mutation Pattern in the Overlapping MHR Region of HBV Isolates in Southern Khorasan, Eastern Iran.
Abstract: The most amino acid substitutions of surface protein were Q129H (34.42%) and A168V (8.2%), other escape mutants observed in this study were P127L/T, S117G, T125M, S143L, D144E and E164D.
Discussion: Sayan reported multiple HBV vaccine-escape mutations (S143T, D144E, G145R, E164D, I195M), of which 3 of them (D144E, S143L and E164D, one case for each) were seen in the current study.
Molecular epidemiology of hepatitis B virus isolated from Bangladesh.
Abstract: A significant number of mutations (Thr118Val, Thr125Met, Thr126Ile, Pro127Thr, Ala128Val, Thr131Asn/Ser, Thr/Ser143Leu/Met) were found in 'a' determinant region which may admit resistance to the availa
Result: Several mutations were observed in 'a' determinant region of S gene such as, T118V, T125M, T126I, P127T, A128V and T/S143L/M according to different genotypes of HBV (Table 1).
Naturally Occurring Surface Antigen Variants of Hepatitis B Virus in Tunisian Patients.
Result: Amino acid substitutions in the major hydrophilic region predicted from nine clones of HBV from the son's sample include L104S, T118K, T123N, S143L and G145A.
HBV mutation literature information.
PMID: 
2017
PloS one
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