Abstract: Different amino acid substitutions were identified in overt infection group: S143L/T (16.2 %, 12/74) and P120T/S (2.7 %, 2/74).
Result: The most prevalent variant was S143L/T detected in 12 (16.2 %) of sequences, followed by T115S in 7 (9.5 %), Q129R in 5 (5.8 %), P120T/S in 2 (2.7 %), and K141R in one (1.4 %).
Result: The most prevalent variant was S143L/T detected in 16.2 % of sequences, followed by T115S in 9.5 %, Q129R in 5.8 %, P120T/S in 2.7 %, and K141R in 1.4 %.
Abstract: Of the 13 HBsAg mutations found in these patients, 8 of 13 (M103I-L109I-T118K-P120A-Y134H-S143L-D144E-S171F) reside in a major hydrophilic loop (target of neutralizing antibodies [Abs]); some of them are already known to hamper HBsAg recognition by humoral response.
S gene mutants occurrence among hepatitis B carriers in malaysia.
Discussion: The MHR region contains residues 99-169 of HBsAg and T/I126S, Q129H, G130N, S143L, D144A, G145A, and G145R were among the commonly reported mutations.
Molecular epidemiology and genotyping of hepatitis B virus of HBsAg-positive patients in Oman.
8Discussion: The identified sT/S143L/M mutations of the HBsAg gene, mapped to loop 2 of the ""a"" determinant, and were thought to be associated with vaccination allowing ongoing replication of HBV."
Table: S143L/M
Discussion: We found the sP120T, sT126S, sM133T, and sT/S143L/M mutations in the HBsAg-positive patients while these mutations have been previously described as possible vaccine escape mutations (reviewed in:).
Occult hepatitis B virus infection in anti-HBs-positive infants born to HBsAg-positive mothers in China.
5Result: Mutation S143L was found in four sequences of genotype C/D in the ""a"" determinant, which is also related to vaccine escape."
Abstract: Escape mutation S143L was found in the four sequences of genotype C/D.
Result: In the S
Discussion: In this study, 4 OBI infants with C/D genotype had S143L mutation, and their HBsAg-negative occult state may be attributed to the escape mutation.
Discussion: identified the OBI-associated mutations Y100S, T116N, R122P, S143L and S167L from a large-sample, blood-donor study.
Characterization of the occult hepatitis B virus variants circulating among the blood donors from eastern India.
Discussion: Mutations related to diagnostic failure (such as M133T/I, F134N, and S143L) including vaccine escape mutations such as D144A and G145R could not be found.
Comprehensive analysis of the prevalence of hepatitis B virus escape mutations in the major hydrophilic region of surface antigen.
Abstract: Eight important mutations associated with diagnostic failure, P120T, T126S, Q129H, G130N, S143L, D144A, and G145A/R, were prevalent in one or more genotypes, with the frequency of no less than 1%.
Novel HBsAg markers tightly correlate with occult HBV infection and strongly affect HBsAg detection.
Abstract: By co-variation analysis, correlations were observed for R122P+
Abstract: Even more, Y100S and Y100S+S143L supernatants show no detectable-HBsAg (experiments in quadruplicate).
Abstract: Mutants (obtained by site-directed mutagenesis) carrying T116N, T116N+S143L, R122P, R122P+Q101R, or R122P+S167L strongly decreased HBsAg-reactivity (54.9+-22.6S/CO, 31.2+-12.0S/CO, 6.1+-2.4S/CO, 3.0+-1.0S/CO and 3.9+-1.3S/CO, respectively) compared to wild-type (306.8+-64.1S/CO).
Monitoring of hepatitis B virus surface antigen escape mutations and concomitantly nucleos(t)ide analog resistance mutations in Turkish patients with chronic hepatitis B.
PMID: 20382061
2010
International journal of infectious diseases
Abstract: In the treatment-naive group the prevalence was 8.1% (15/185), with the following patterns: sL109I, sI110V, sS117INST, sP120T, sP127T, sM133I, sC137L+sG145R, sS143L.
Molecular characterization of hepatitis B virus (HBV) isolates, including identification of a novel recombinant, in patients with acute HBV infection attending an Irish hospital.
Abstract: Variations within the S gene were identified in 6 isolates, including Gly145Ala, associated with vaccine immune escape, Asp144Glu, Ser143Leu and Phe134Leu, each associated with failure to detect HBsAg.
HBV mutation literature information.
PMID: 
2015
Virology journal
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