Abstract: CONCLUSION: ELISA-based detection of escape mutations S143L, D144E and G145R can be used for routine diagnostics, especially in the risk groups.
Abstract: The kit specifically recognized the S143L substitution in contrast to the S143T variant.
Recombinant HBsAg of the Wild-Type and the G145R Escape Mutant, included in the New Multivalent Vaccine against Hepatitis B Virus, Dramatically Differ in their Effects on Leukocytes from Healthy Donors In Vitro.
Introduction: Electron microscopy revealed unusual oval-shaped 60-70 nm HBV structures in serum and 100-200 nm structures in a preparation of the purified G145R mutant, which were not seen in samples of wild-type HBV or an S143L escape mutant.
Introduction: In addition, studies of sera from vaccinated people have shown that the widely used vaccines provide virtually no cross-reactive protection against the G145R mutant in the virus neutralization assay, in contrast to, for example, another immune-escape mutant S143L.
Characterization of Antigen Escape Mutations in Chronic HBV-Infected Patients in Upper Egypt.
Discussion: T115S, P120T, T125M, P127T, Q129R, K141R, and S143L were HBV mutants recorded among Egyptian blood donors with occult infection.
Discussion: S143L, G145R/A, and D144E/A were the highest reported mutations among our cohort, which were detected in 25%, 20%, and 15% of the patients, respectively.
Discussion: Ma and Wang reported that eight mutations (
Discussion: Similar to our findings, Zeid et al reported that S143L mutation is the predominant mutation (6.8%) among Egyptian CHB patients.
Global prevalence and phylogeny of hepatitis B virus (HBV) drug and vaccine resistance mutations.
Method: We also considered eight VEMs (C139S, S/T140I, P142S, S/T143L/M, D144A/E/G/N, G145A/E/R, K141A/I/R and C147S) which are located within the epitope region neutralized by the HBV vaccine (aa139-147).
Result: We considered the distribution of 12 RAMs (S106C/G, D134E, R153W/Q, V173L, L180M, A181T/V, A194T, A200V, PMID: 33836203
2021
Virus research
Abstract: Additionally, 11 occult samples (19 %) were detected, in which the predominant mutations of HBsAg were S143L (7 samples) followed by D144A and T125M (4 samples each).
Molecular Epidemiology of Hepatitis B Virus in Turkish Cypriot.
PMID: 31880889
2019
Polish journal of microbiology
Table: S143L
Patterns of hepatitis B virus S gene escape mutants and reverse transcriptase mutations among genotype D isolates in Jordan.
Introduction: Among other commonly detected vaccine-escape mutants are: P120Q, Q129H, F134Y/L, S143L and D144A/E.
Discussion: In Turkey, the most frequent mutations observed were T143M and K122R, whereas in Egypt 14.8% presented with mutations in the MHR, and eight different mutations were discovered: R122K, S143L, L109P, S114P, S117N, P127S, P127T and Y134F.
Hepatitis B infection among HIV infected individuals in Gabon: Occult hepatitis B enhances HBV DNA prevalence.
Method: In addition, we looked for Vaccine Escape Mutants (VEMs) and polymorphic mutations outside (Y100C, Q101H, S117N, T118R and P120S) and within the HBsAg immuno-dominant 'a' determinant (I/T126A/N, A128V, Q129H/R, G130N, M133L/T, K141E, S143L, D144A/H/E and G145R).
High rates of chronic HBV genotype E infection in a group of migrants in Italy from West Africa: Virological characteristics associated with poor immune clearance.
Abstract: RT sequence analysis showed the presence of a number of immune escape mutations: strains from all of the patients had a serine at HBsAg position 140; 3 also had T116N, Y100C, and P142L+S143L substitutions; and 1 had a G112R substitution.
Result: Additional immune escape mutations were detected in 3 patients: T116N, Y100C, and P142L+S143L (Fig 1).
Characteristics of escape mutations from occult hepatitis B virus infected patients with hematological malignancies in South Egypt.
Result: Of the 12 samples, escape mutation Q129R was present in 7, while P120T was detected in 4 and S143L was present in 1, suggesting that the clones with 129R mutation were from a minor population with relatively low HBV-DNA levels.
Table: S143L
Figure: Expression of hepatitis B virus DNA and antigens after transfection of Huh 7 cells with wild type hepatitis B virus genotype D clone (WT) and mutants with S<
Discussion: We detected two previously reported escape mutations P120T and S143L that were associated with occult HBV infection, and investigated the mechanism by which these mutations cause occult infection using an in vitro system.
HBV mutation literature information.
PMID: 
2022
Voprosy virusologii
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