Abstract: Four sites (
A5T/S,
L21S,
T/A126S and
T/N131I/A) and 13 sites (
N3S,
T5A,
G10Q/R/E,
L21S,
T47K/A/V,
L98V/P,
I/S126N/V/T,
Q129H/R/L,
T131P/I/N/A,
G145A/R,
L175S/F,
L213I/S,
V224A/G) were found to be under positive selection in genotype B and C HBV vaccine escape strains, re