literature

HBV mutation literature information.

Characterization of Hepatitis B virus polymerase mutations A194T and CYEI and tenofovir disoproxil fumarate or tenofovir alafenamide resistance.

PMID: 32894807 2021 Journal of viral hepatitis

Abstract: Both the A194T and a quadruple mutation CYEI (S106C, H126Y, D134E and L269I) in hepatitis B virus (HBV) polymerase reverse transcriptase domain (pol/RT) are suggested to be associated with treatment failure with tenofovir disoproxil fumarate (TDF).

Virologic analysis of tenofovir resistance in a patient with chronic hepatitis B experiencing viral breakthrough during combination treatment with tenofovir disoproxil fumarate and entecavir.

PMID: 33462964 2021 Hepatology research

Abstract: A recent Korean report showed tha

Abstract: Four mutations (rtS106C, rtD134N/S[N/S], rtM204V, and rtL269I) plus ETV resistance (rtL180M and rtS202G) existed when she developed viral breakthrough during ETV and TDF combination therapy in April 2013.

Abstract: Moreover, three mutations (rtS106C, rtD134N, and rtL269I) existed at baseline.

Distinctive HBV Replication Capacity and Susceptibility to Tenofovir Induced by a Polymerase Point Mutation in Hepatoma Cell Lines and Primary Human Hepatocytes.

PMID: 33562603 2021 International journal of molecular sciences

Method: Two clones (CYEI: rtS106C (C) + rtH126Y (

Discussion: Nevertheless, some recent studies have shown that rtS78T/sC69*, rtS106C/rtH126Y/rtD134E/rtL269I, and rtL180M/T184L/M204V/rtA200V are related to TDF resistance.

Global prevalence and phylogeny of hepatitis B virus (HBV) drug and vaccine resistance mutations.

PMID: 33893696 2021 Journal of viral hepatitis

Result: We considered the distribution of 12 RAMs (S106C/G, D134E, R153W/Q, V173L, L180M, A181T/V, A194T, A200V, M204I/V, L217R, L229V/W and I269L) and eight VEMs (C139S, S/T140I, P142S, S/T143L/M, D144A/E/G/N, G145A/E/R, K141A/I/R and

Investigation of immune escape-associated mutations of hepatitis B virus in patients harboring hepatitis B virus drug-resistance mutations.

PMID: 32994690 2020 World journal of gastroenterology

Introduction: In addition, rtS106C+rtH126Y+rtD134E+rtL269I quadruple mutations have recently been reported to confer TDF resistance.

Identification of a quadruple mutation that confers tenofovir resistance in chronic hepatitis B patients.

PMID: 30794889 2019 Journal of hepatology

Abstract: RESULTS: Five mutations (rtS106C [C], rtH126Y [Y], rtD134E [E], rtM204I/V, and rtL269I [I]) were commonly found in viral isolates from 2 patients.

Effects of amino acid substitutions in hepatitis B virus surface protein on virion secretion, antigenicity, HBsAg and viral DNA.

PMID: 27650283 2017 Journal of hepatology

Result: Due to the overlapping nature of the S and RT gene regions, mutations in the S gene may result in concomitant mutations in RT, such as sC69*/rtS78T, sL98V/rtS106C and sG145R/rtR153Q, potentially affecting RT activity and HBV replication.

Characterization of the occult hepatitis B virus variants circulating among the blood donors from eastern India.

PMID: 24302857 2013 TheScientificWorldJournal

Result: Multiple mutations were found in the A-B interdomain region, such as rtI91L, rtL93P, rtS106C, rt Discussion: A recent study from South India reported the presence of rtS106C mutation among the chronic HBV carriers.

Discussion: In the BCP region mutations such as 1752C, only 1753C, 1753C + 1762T/1764A (triple mutation), and 1762T/1764A (double mutation) are noteworthy, and in HBVrt region, rtS106C mutation was found among the OBI isolates.

Prevalence and significance of Hepatitis B reverse transcriptase mutants in different disease stages of untreated patients.

PMID: 22882650 2012 Liver international

Abstract: The naturally occurring mutation, rtS106C mutation was higher in chronic hepatitis B patients (14/100, 14.0%) and cirrhotic patients (14/100, 14.0%) than that in hepatocellular carcinoma patients (4/100, 4.0%, P = 0.013).

Discussion: The rtS106C and rtD134E/G/N/S mutations may be an induced consequence from the overacting immune response towards severe necro-inflammation seen during different disease stages of CHB.

Discussion: The immune response towards active

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