Discussion: In another study in Iran, P120T/S and R122K/T were found in 4% of patients, and G145R was found only in one case; which none of them occurred in the current project.
Mutations in the S gene region of hepatitis B virus genotype D in Golestan Province-Iran.
Result: T113S, S114T, R122K, I126T and P127L were the most frequent in both asymptomatic and symptomatic patients; whereas A159G, R160K, F161Y and V168A were more frequent in symptomatic patients.